respiratory drugs Flashcards
defense mechanisms of the resp. system
turbinates, hiar, coughing, sneezing, spasms, mucus secretions, cilia, IgA
3 principles of resp. therapy
control secretions, control reflexes, maintain airflow to alveoli
how do we control secretions
- production, + elimination, remove cause of secretion (antibiotics, antifungal, antiparasitic), make secretions less viscid
how do we control reflexes
suppress cough, control sneezing, control bronchospasms
maintaining flow of alveoli
reverse bronchoconstriction, remove edema mucus, provide O2 therapy
another name for aerosolization
nebulization
what is aerosolization
allows delivery of drugs at high concentrations directly to airways with minimal blood level
what factors affect distribution of drug
size of inhaled particles, must be 1-5 microns, presence of mucus or exudate, bronchodilator
8 categories of resp drugs
expectorants, mucolytics, bronchodilators, decongestants, antihistamines, corticosteroids, misc.
expectorant
drugs that liquify and dilute viscous secretions (used for productive coughs)
example of expectorant
guaifenesin
adverse effects of expectorant
few, nausea and drowsiness
mucolytic
drugs that breaks down chemical structure of mucous viscosity
example of mucolytic
acetylcysteine (nebulized) oral or iv used for acetaminophen toxicity
adverse effects of mucolytic
nausea
antitussive
drug that suppresses cough
how does antitussive work
only used for non-productive cough, can be central or peripheral
central acting antitussive
suppresses cough center of the brain
peripheral-acting antitussive
cough drops, depress cough receptors in airways
example of antitussives
butorph, codeine, dextromethorphan, temaril-P, hydrocodone bitartrate