hormonal and repro drugs Flashcards

1
Q

chemical messengers produced by cells in one part of the body and transported to another that influences cellular activity

A

hormone

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2
Q

negative feedback

A

response to low or high levels of hormones in the body

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3
Q

positive feedback

A

hormone levels continue to rise due to stimulus

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4
Q

anterior pituitary hormones used in vet practice

A

TSH, ACTH, FSH, LH, GH

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5
Q

posterior pituitary hormones used in practice

A

ADH, oxytocin

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6
Q

TSH

A

used in Dx for hypothyroidism

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7
Q

ACTH

A

used to stimulate adrenal cortex for hypo and hyperadrenocorticism

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8
Q

FSH and LH

A

for reproduction

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9
Q

GH

A

used to increase growth rate and feed use efficiency in livestock and increase milk production

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10
Q

insulin

A

responds to rise in blood glucose and promotes uptake of glucose for energy in cells (lowers BG)

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11
Q

glucagon

A

increases blood glucose levels by promoting the breakdown of glycogen into glucose (increases BG)

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12
Q

diabetes mellites

A

disease of fat, carb, and protein metabolism caused by lack of insulin

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13
Q

clinical signs of diabetes mellitus

A

PU, PD, PP, weight loss

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14
Q

how to treat diabetes mellitus

A

diet and meds

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15
Q

DKA

A

diabetic ketoacidosis

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16
Q

hallmark of diabetes mellitus

A

persistent fasting hyperglycemia

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17
Q

insulin must be given ____ and cannot be given_____

A

with food, orally

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18
Q

insulin

A

used to treat DM by keeping glucose in proper range

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19
Q

short-acting insulin

A

used for initial treatment of DKA that lasts 1-2 hours
ex. humulin R, novolin R

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20
Q

intermediate-acting insulin

A

used to control blood glucose in uncomplicated cases of DM lasts 12 hours
ex. humulin N, novolin N, vetsulin

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21
Q

long-acting insulin

A

used to control blood glucose for longer periods of time, especially in cats, lasts 12-18 hrs
ex. glargine, detimir, prozinc

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22
Q

measuring insulin

A

units of insulin/ mL (U-40, U-100, U-500) 1 unit= 0.01 ml

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23
Q

U-100 insulin is _____ stronger than U-40

A

2.5 times

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24
Q

oral hypoglycemic agents are _____

A

not typically done

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25
hyperglycemic agents
only used for insulinoma
26
function of thyroid gland
metabolism, regulation of body temp, HR, skin health
27
hormones from thyroid
T4 or T3
28
abnormalities in thyroid
hyper and hypo thyroidism
29
hypothyroidism
decreased coat condition, loss of hair, bilateral flank alopecia, weight gain, puffy
30
thyroid therapy
levothyroxine (T4)
31
hyperthyroidism
increased thirst, weight loss, ++ defecation, tachycardia, palpable thyroid
32
treatment for hyperthyroidism
I-131 (iodine), methimazole
33
the adrenal cortex releases what
mineralocorticoids (aldosterone) and glucocorticoids (cortisol)
34
hypoadrenocorticism
adrenocortical insufficiency, middle aged female dogs, lethargy, weakness, low BP, anorexia, vomiting, diarrhea, low Na+, elevated K+, azotemia
35
Dx addisons
ACTH stimulation test
36
Tx for addisons
corticosteroids-dexamethasone, fludrocortisone, desoxycorticosterone
37
hyperadrenocorticism
PU, PD, PP, hair loss, pot belly
38
Dx cushings
ACTH or dexamethasone test
39
Tx cushings
trilostane ****
40
key hormone in reproduction
gonadotropin releasing hormone, stimulate gonads
41
FSH
follicle stimulating hormone
42
LH
causes maturation of the follicle in ovulation
43
after ovulation, the follicle is called ______ and releases _______
corpus luteum, progesterone
44
human chorionic gonadotropin (hCG)
used to treat cystic ovaries in cattle, detect cryptorchidism in dogs, get infertile bitches to cycle, and make breeding mares ovulate
45
pregnant mare serum gonadotropin (PMSG)
used to stimulate cycle and ovulation in mares, follicle stim in many species
46
gonadorelin (GnRH)
treat follicular cysts in cattle, estrus synch in cattle, induce estrus in many species
47
testosterone
made in interstitial cells, used to treat infertility and hypogonadism, and urinary incontinence (CIII)
48
mibolerone
blocks release of LH from anterior pituitary gland and follicle does not develop, used to develop estrus in dogs and prevent false pregnancies, not safe for cats
49
progesterone
decreases uterine activity in estrus or pregnant female, used to treat behavior problems and some dermatitis
50
examples of progesterone
megestrol, medroxyprogesterone acetate, altrenogest, progesterone, melengestrol
51
control estrus and false pregnancy, dermatologic conditions in cats
megestrol acetate (ovaban, megace)
52
side effects of megestrol acetate
endometrial hyperplasia, adrenal depression
53
suppress estrus in dogs and cats
medroxyprogesterone acetate (Depo-provera)
54
side effects of medroxy
pyometra, mammary changes
55
suppress estrus in mares, supplement for progesterone for pregnancy
altrenogest (Regu-mate)
56
synch estrus in cattle, used with estrogen
Norgestomet (synchro-mate-b)
57
uses of estrogen
female sex characters, prevent implantation of ova, aid in expulsion of expelled placenta, induce estrus in non-breeding season in horses
58
examples of estrogen
estradiol cypionate, diethylstilbestrol, incurin
59
prostaglandins
causes lysis to corpus luteum which initiates estrus, used to treat pyometra and abortions, synch estrus in cattle and horses
60
examples of prostaglandins
dinoprost, fluprostenol, cloprostenol
61
how are growth promotants prepared for sheep and cattle (promote weight gain)
compressed pellets implanted SQ into ear
62
examples of growth promotants
estradiol, test, progesterone, trenbolone, zeranol
63
anabolic steroids
tissue building affect, synthetic, CIII (stanozolol)