Resp Patho Flashcards
In obstructive pulmonary disorders, do inspiration or expiration require more force?
Expiration
Unifying symptom of obstructive pulmonary disorder
Dyspnea
Unifying sign of obstructive pulmonary disorder
Wheezing
3 most common obstructive pulmonary disorders
Asthma
Chronic bronchitis
emphysema
What 2 disorders fall under chronic obstructive pulmonary disease (COPD)?
Chronic bronchitis
Emphysema
What is tidal volume (TV) of a normal individual?
400-800 ml
How many breaths per minute is normal?
8-16
How is normal breathing described?
Rhythmic and effortless
What is when there is inadequate alveolar ventilation ?
Hypoventilation
What is when there is excessive alveolar ventilation?
Hyperventilation
When can a person enter a state of acidosis?
Hypoventilation
What is a reflex to clear airways? (larynx area)
Cough
What is selective bulbous enlargement at the end of a digit?
Clubbing
What are the 3 diseases that are obstruction from conditions in the wall of the lumen?
Asthma
Acute Bronchitis
Chronic Bronchitis
What disorder has a chronic, constant, inflammation in the airway?
Asthma
What is the major pathological feature of asthma?
Inflammation creating hyperresponsiveness of airway
What are the 2 types of asthma attacks?
Slow-onset acute Hyperacute asthma (minutes to hours)
What separates acute bronchitis from pneumonia?
Bronchitis has clear chest films
What does the bacterial form of bronchitis have?
Productive cough with fever and sternal pain
What type cough does viral acute bronchitis usually have?
Non-productive
How long must a productive cough must continue to be classified as chronic bronchitis?
At least 3 months of the year for at least 2 consecutive years
What cells increase in chronic bronchitis?
Mucous glands and goblet cells in airway epithelium
What are individuals with chronic bronchitis referred to as?
Blue bloaters
What is abnormal permanent enlargement of acini accompanied by destruction of alveolar walls without obvious fibrosis?
Emphysema
Why is emphysema an obstructive disorder?
Can’t push air out due to loss of elastic tissue
What is primary emphysema?
Deficiency of enzyme alpha I-antitrypsin
Autosomal recessive
What does a person with emphysema look like?
Thin
Tachypnea
Increased chest diameter
What is an individual with emphysema described as ?
Pink Puffer
What are 5 obstructive disorders of the airway lumen?
Bronchiectasis Bronchiolitis Acute tracheobronchial obstruction Epiglottitis Croup syndrome
What is a persistent abnormal dilation of bronchi?
Bronchiectasis
What are the three types of bronchiectasis?
Cylindrical- Symmetrically dilated airways
Saccular- Bronchi become large and balloon like
Varicose- Deform bronchi overtime due to constrictions and dilations
What is Inflammatory obstruction of small airways or bronchioles?
Bronchiolitis
Is bronchiolitis more common in adults or children?
Children, but can occur in adults with chronic bronchitis
What is a blockage of trachea or bronchi?
Acute tracheobronchial obstruction
What lung is affected by acute tracheobronchial obstruction?
Right
What was epiglottitis historically caused by?
H. influenza type b
What age group does epiglottitis affected?
2-6
What signs are associated with epiglottitis?
High fever
store throat
inspiratory stridor
severe respiratory distress
What is laryngotracheobronchitis?
Croup syndrome
What is the cause of croup?
Sub-glottic edema from infection
What is the most critical region with croup syndrome?
cricoid region
What syndrome has a seal-like barking cough?
Croup
What is ARDS?
Acute respiratory distress syndrome
Acute lung inflammation and diffuse alveolcapillary injury
What do all disorders that cause ARDS do?
acutely injure the alveolocapillary membrane and cause severe pulmonary edema
What is the hallmark of ARDS?
Increased capillary permeability
What is the main cell associated with ARDS?
Neutrophils
What are hyaline membranes (ARDS)?
Fibrosis areas that replace alveoli
What is FRC?
Functional reserve capacity
What happens to FRC with ARDS?
It is decreased
What is IRDS?
Infant respiratory distress syndrome
What is IRDS a disease of?
Hyaline membrane disease
What do ARDS and IRDS have in common?
Development of hyaline membranes
What population does IRDS occur in?
Premature infants (born before 30 weeks)
What is the primary cause of IRDS?
Lack of pulmonary surfactant
What causes hyaline membrane formation in IRDS?
leak of fluid into alveoli