Resp 2.1 Flashcards

1
Q

In contrast to expiration, inspiration is

A

un phénomène actif au cours duquel le volume
thoracique augmente.

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2
Q

Muscles d’inspiration au repos?

A

Intercosteaux externes, diaphragm

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3
Q

Muscles inspiratoire accessoire? When are they used?

A

petit pectoral,
scalènes,
sterno-cleido-mastoïdiens

Mostly used when need to have hardcore inspiration due to an exercise

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4
Q

Expiration forcée

Careful, not the same and inspiration force!!

A

Used when there is some block in the resp system, when we need to cough etc

Need muscles expiratoires accessoires:
muscles abdomineaux, muscles intercosteaux internes

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5
Q

Toute variation de volume entraine

A

Toute variation de volume entraine une variation de pression. Le produit : P x V = constante P and V are inversely correlated!

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6
Q

2 players in generating the neccessary pressure differences for gas exhange?

A

The thoracic cage and the lungs

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7
Q

True or false:
Le volume pulmonaire est égal au volume thoracique

A

True

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8
Q

les résistances statiques centripètes et centrifuges

A

centripètes (pulmonaires) et
centrifuges (thoraciques)

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9
Q

Lungs have resistance statique centripede, what does it mean and why?

A

It means that the lungs have a natural tendancy to collapse on themselves
Two reasons:
Due to the nature of the cells -> elasctic
Due to** tension de surface** du liquide tapissant les alvéoles -> water molecules sorrounding alveoli that want to stay together holding hands

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10
Q

Surfactant and surface tension?

A

Surfactant (secreted by pnemocytes type 2) is a lipoprotein that reduces the surface tension of the liquid lining the alveoli by reducing the contact of water molecules to water.

It prevents the alveoli from collapsing during expiration

It increases the lung compliance, or the ease of lung expansion

It reduces the work of breathing by decreasing the resistance to airflow in the airways.

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11
Q

What is the effect on lung expiration complience if we fill the lungs with water instead of air

A

Saline is a solution of salt and water that has a lower surface tension than pure water. This means that saline molecules are less strongly attracted to each other than water molecules, and therefore create less force that tends to collapse the alveoli.

filling the lungs with saline instead of air would increase the lung compliance, -> ease of lung expansion, by making the lung tissue more elastic and flexible

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12
Q

What is propriétés élastiques du thorax (centrifuge)?

A

The thorac is kinda the inverse of lungs. As much as lungs want to collapse on themselves, the thorac wants to expand

Depending on the muscle work, these two can balance each other, the thorac wanting to expand and the lungs wanting to collapse.

For example during inspiration when the expansion of the thoracic cavity is larger this essentially beats though tendency of the lungs to collapse leading to an expansion of the lungs

propriétés élastiques génèrent la pression intrapleurale négative -> which allows for the expansion of lungs

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13
Q

What is the effect of fibrosis (a disease that decreases lung complienece)

A

It makes it harder to breather because for the same amout of air, the amount of negative pressure that needs to be generated is higher!

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14
Q

We learned that there is an amount of air volume called “resting volume” why does this happen at a specific point?

A

As you breathing you create negative pressure inside your lungs

this is done by the expansion of the thorax however at some point after you expanded above 75% of total volume your thorax will start having a tendency to go back to its initial form because you have expanded so much

you can look at the opposite, when you are breathing air out initially it is easier because the thorax as a tendency to go back to a stable point

the reason why we have a resting volume of air is because there’s a specific point where the tendency of the thorax to expand is the same as the tendency of the lungs to collapse -> equilibrium

review page 30

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15
Q

What is Pneumothorax and effect?

A

accumulation d’air entre la plèvre pariétale et la plèvre viscérale

Effect:
the air in the pleural space creates pressure on the lung, preventing it from expanding normally when you breathe causing the lung to collapse partially or fully.

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16
Q

Speed of air through the respiratory tract and what contributes to this?

A

flot de l’air très rapide dans les voies aériennes supérieures devient de plus en plus lent à mesure que la résistance augmente avec les embranchements (as you go to tiny alveoly from large trachea)

What contributes to this:
Muscle lisse bronchique -> tonus du muscle lisse bronchiolaire change le calibre ou le diamètre des voies aériennes et la résistance par
friction au mouvement des gaz
bronchodilatation = less resistance = more speed = more air exchange and vice versa

17
Q

trois systèmes intervenant
dans la bronchomotricité

A

système adrénergique- > systeme sympathique -> dilatation
système cholinergique -> acetylcholine -> parasympathetic -> vasoconstriction
système NANC

18
Q

épithélium pseudo-stratifié à cellules ciliées, what is the role?

A

Found in bronches

It is key to catch debris passing in the respiratory tract and to eliminate them

19
Q

Dans les conditions physiologiques, le tonus ______________ prédomine.

A

parasympathique bronchoconstricteur

20
Q

Système nerveux parasympathique effect on bronche

A

This is the system that integrates afferent information from mechanoreceptors, thermoreceptors and chemoreceptors and then via efferent projections (nerf vague; acetylcholine) can cause a vasoconstriction or release of mucus etc

there are 3 types of important muscarinic receptors:
**M1: **situés niveau du ganglion dans la paroi bronchique et facilitent la neurotransmission.
**M2: **they play a retrograde control role, modulating the release of acetylcholine
M3: situés au niveau du muscle lisse bronchique. Ils permeLent la contraction du muscle

*M3 is a key theurapeutic target as you can essentially dilate bronches by inhibiting the effect of the parasympathetic nervous system on M3 (EXAM, EXAM EXAM) *

21
Q

Système NANC

A

rameaux différenciés à par9r du système parasympathique afférent ou
efférent

it works by releasing small peptides and can have an inhibitory or excitatory effect

NOTE THAT THIS SYSTEM IS INDEPENDENT OF ADRENALINE AND ACETYLCHOLINE AND THUS A BLOCKER OF THESE CANNOT INFLUENCE IT