Renal Pathology II

Question 1

REVIEW

What are the 3 causes of nephritic hematuria?

Answer 1

1) postinfectious
2) IgA
3) hereditary

Question 2

What are the 3 causes of severe nephritic syndrome?

Answer 2

rapidly progressive glomerulonephritis I, II, and III

Question 3

What is a major feature of RPGN?

Answer 3

crescents (severe glomerular basement membrane injury - can allow leakage of blood and fibrin into bowman space)

Question 4

What is a glomerular crescent and why is it dangerous?

Answer 4

pool of blood that compresses tuft which decreases GFR (leading to rapid renal failure)

Question 5

What two things leak into Bowman’s space in glomerular crescents?

Answer 5

fibrin and blood

also macrophages

Question 6

What are the 3 causes of pathogenesis in glomerular crescents?

Answer 6

1) anti-glomerular basement membrane antibody (RPGN I)
2) IC glomerulonephritis (RPGN II)
3) pauci-immune/ANCA associated (RPGN III)

Question 7

What is the pathogenesis of RPGN type I?

Answer 7

anti-glomerular basement membrane antibody (anti-GBM)

Question 8

What is the presentation of RPGN I?

Answer 8

1) gross hematuria (holes in BM)
2) drop in urinary output
3) hemoptysis

Question 9

What are the classic demographics of RPGN I?

Answer 9

young men

Question 10

What does RPGN look like under IF?

Answer 10

antibody deposited along the entire length of the glomerular basement membrane (leads to necrosis and holes in the BM –> hematuria)

Question 11

What is Goodpasture syndrome?

Answer 11

autoimmune antibody cross-reactivity with pulmonary alveolar basement membrane