Normal Hemostasis

Question 1

What are the 3 things required for hemostasis?

Answer 1

endothelium
platelets
coagulation/fibrinolysis

Question 2

What is the first step of hemostasis?

Answer 2

vasoconstriction

Question 3

What are the 5 steps of primary hemostasis?

Answer 3

1) platelet adhesion
2) shape change
3) granule release (ADP, TXA2)
4) recruitment
5) aggregation (hemostatic plug)

Question 4

What are the 4 steps of secondary hemostasis?

Answer 4

1) tissue factor release
2) phospholipid complex expression
3) thrombin activation
4) fibrin polymerization

Question 5

What polymerizes fibrin?

Answer 5

factor 13a

Question 6

What are 2 big roles of thrombin?

Answer 6

1) recruits and activates additional platelets

2) converts fibrinogen to fibrin

Question 7

What 2 things do endothelium cells secrete to keep normal blood vessels in antithrombotic effect?

Answer 7

prostacyclin

nitric oxide

Question 8

What factors are responsible for promoting the anticoagulant state?

Answer 8

Thrombomodulin binds to thrombin activating protein C (natural anticoagulant)

protein S = cofactor for protein C

Question 9

What does antithrombin combine with to inhibit thrombin?

Answer 9

heparin-like molecules

Question 10

___________ activates the extrinsic coag cascade and is secreted by _____________

Answer 10

tissue factor

endothelial cells