Renal IV: Nephritic Syndrome

Question 1

Features of Nephritic Syndrome

Answer 1

Reduction in GFR, Hematuria, Proteinuria, Edema, Hypertension

Question 2

What disease process? Aggressive treatment with steroids, immunosuppressive agents, and plasma exchange

Answer 2

anti-GBM disease

Question 3

What disease process? ANA+

Answer 3

Lupus Nephritis

Question 4

What disease process? ANCA+

Answer 4

pauci-immune vasculitis

Question 5

What disease process? Binding of antibody to Type IV collagen antigens in the GBM

Answer 5

anti-GBM disease

Question 6

What disease process? C-ANCA+

Answer 6

Granulomatosis with Polyangiitis (GPA)

Question 7

What disease process? Cause of pulmonary-renal syndrome

Answer 7

Goodpasture Syndrome; pauci-immune vasculitis

Question 8

What disease process? Classically seen after Group A strep infection

Answer 8

Post-Infectious Glomerulonephritis

Question 9

What disease process? Elevated ASO titer

Answer 9

Post-Infectious Glomerulonephritis

Question 10

What disease process? Fibrinoid necrosis, crescents, no immune complexes

Answer 10

pauci-immune vasculitis

Question 11

What disease process? Focal proliferative necrotizing glomerulonephritis with crescent formation

Answer 11

Henoch-Schonlein purpura

Question 12

What disease process? Form of glomerulonephritis most commonly seen in children

Answer 12

Post-Infectious Glomerulonephritis

Question 13

What disease process? Granular deposits of IgG and C3 in subepithelial, mesangial, and subendothelial regions

Answer 13

Post-Infectious Glomerulonephritis

Question 14

What disease process? IgG and C3 in a mesangial pattern

Answer 14

MPGN

Question 15

What disease process? IgG, IgA, and C3 in a mesangial pattern

Answer 15

IgA Nephropathy

Question 16

What disease process? Immune complex deposition in the walls of vessels

Answer 16

Cryoglobulinemia

Question 17

What disease process? Linear immunofluorescence

Answer 17

anti-GBM disease (Goodpasture disease)

Question 18

What disease process? May present with gross hematuria with onset of a viral illness

Answer 18

IgA Nephropathy

Question 19

What disease process? Membranoproliferative pattern with subendothelial immune deposits

Answer 19

Cryoglobulinemia

Question 20

What disease process? Most common in men 15-35 years of age

Answer 20

IgA Nephropathy

Question 21

What disease process? Most common type of acute glomerulonephritis

Answer 21

IgA Nephropathy

Question 22

What disease process? Most patients resolve spontaneously

Answer 22

Post-Infectious Glomerulonephritis

Question 23

What disease process? MPGN with a predominance of IgA immune deposits

Answer 23

IgA Nephropathy

Question 24

What disease process? Neutrophil infiltration and extensive crescent formation

Answer 24

anti-GBM disease, pauci-immune vasculitis

Question 25

What disease process? Often post-URI causes; seen in children

Answer 25

Henoch-Schonlein purpura

Question 26

What disease process? P-ANCA+

Answer 26

Microscopic Polyangiitis (MPA)

Question 27

What disease process? Palpable purpura, arthralgias, weakness

Answer 27

Cryoglobulinemia; Henoch-Schonlein Purpura

Question 28

What disease process? Postive for C1q, C3, IgM, IgG, and IgA

Answer 28

Lupus Nephritis

Question 29

What disease process? Rapidly progressive glomerulonephritis with possible pulmonary hemorrhage

Answer 29

Goodpasture Syndrome

Question 30

What disease process? Some combination of C-ANCA+ and P-ANCA+

Answer 30

Churg-Strauss

Question 31

What disease process? Sudden weight gain upon presentation

Answer 31

Post-Infectious Glomerulonephritis

Question 32

What disease process? Triad of ocular disturbances, nephritis, and deafness

Answer 32

Alport Syndrome

Question 33

What disease process? X-linked mutation in Type IV collagen that prevents formation of normal basement membranes

Answer 33

Alport Syndrome