Renal IV: Nephritic Syndrome Flashcards
Features of Nephritic Syndrome
Reduction in GFR, Hematuria, Proteinuria, Edema, Hypertension
What disease process? Aggressive treatment with steroids, immunosuppressive agents, and plasma exchange
anti-GBM disease
What disease process? ANA+
Lupus Nephritis
What disease process? ANCA+
pauci-immune vasculitis
What disease process? Binding of antibody to Type IV collagen antigens in the GBM
anti-GBM disease
What disease process? C-ANCA+
Granulomatosis with Polyangiitis (GPA)
What disease process? Cause of pulmonary-renal syndrome
Goodpasture Syndrome; pauci-immune vasculitis
What disease process? Classically seen after Group A strep infection
Post-Infectious Glomerulonephritis
What disease process? Elevated ASO titer
Post-Infectious Glomerulonephritis
What disease process? Fibrinoid necrosis, crescents, no immune complexes
pauci-immune vasculitis
What disease process? Focal proliferative necrotizing glomerulonephritis with crescent formation
Henoch-Schonlein purpura
What disease process? Form of glomerulonephritis most commonly seen in children
Post-Infectious Glomerulonephritis
What disease process? Granular deposits of IgG and C3 in subepithelial, mesangial, and subendothelial regions
Post-Infectious Glomerulonephritis
What disease process? IgG and C3 in a mesangial pattern
MPGN
What disease process? IgG, IgA, and C3 in a mesangial pattern
IgA Nephropathy
What disease process? Immune complex deposition in the walls of vessels
Cryoglobulinemia
What disease process? Linear immunofluorescence
anti-GBM disease (Goodpasture disease)
What disease process? May present with gross hematuria with onset of a viral illness
IgA Nephropathy
What disease process? Membranoproliferative pattern with subendothelial immune deposits
Cryoglobulinemia
What disease process? Most common in men 15-35 years of age
IgA Nephropathy
What disease process? Most common type of acute glomerulonephritis
IgA Nephropathy
What disease process? Most patients resolve spontaneously
Post-Infectious Glomerulonephritis
What disease process? MPGN with a predominance of IgA immune deposits
IgA Nephropathy
What disease process? Neutrophil infiltration and extensive crescent formation
anti-GBM disease, pauci-immune vasculitis
What disease process? Often post-URI causes; seen in children
Henoch-Schonlein purpura
What disease process? P-ANCA+
Microscopic Polyangiitis (MPA)
What disease process? Palpable purpura, arthralgias, weakness
Cryoglobulinemia; Henoch-Schonlein Purpura
What disease process? Postive for C1q, C3, IgM, IgG, and IgA
Lupus Nephritis
What disease process? Rapidly progressive glomerulonephritis with possible pulmonary hemorrhage
Goodpasture Syndrome
What disease process? Some combination of C-ANCA+ and P-ANCA+
Churg-Strauss
What disease process? Sudden weight gain upon presentation
Post-Infectious Glomerulonephritis
What disease process? Triad of ocular disturbances, nephritis, and deafness
Alport Syndrome
What disease process? X-linked mutation in Type IV collagen that prevents formation of normal basement membranes
Alport Syndrome
