Renal IV: Nephritic Syndrome Flashcards
Features of Nephritic Syndrome
Reduction in GFR, Hematuria, Proteinuria, Edema, Hypertension
What disease process? Aggressive treatment with steroids, immunosuppressive agents, and plasma exchange
anti-GBM disease
What disease process? ANA+
Lupus Nephritis
What disease process? ANCA+
pauci-immune vasculitis
What disease process? Binding of antibody to Type IV collagen antigens in the GBM
anti-GBM disease
What disease process? C-ANCA+
Granulomatosis with Polyangiitis (GPA)
What disease process? Cause of pulmonary-renal syndrome
Goodpasture Syndrome; pauci-immune vasculitis
What disease process? Classically seen after Group A strep infection
Post-Infectious Glomerulonephritis
What disease process? Elevated ASO titer
Post-Infectious Glomerulonephritis
What disease process? Fibrinoid necrosis, crescents, no immune complexes
pauci-immune vasculitis
What disease process? Focal proliferative necrotizing glomerulonephritis with crescent formation
Henoch-Schonlein purpura
What disease process? Form of glomerulonephritis most commonly seen in children
Post-Infectious Glomerulonephritis
What disease process? Granular deposits of IgG and C3 in subepithelial, mesangial, and subendothelial regions
Post-Infectious Glomerulonephritis
What disease process? IgG and C3 in a mesangial pattern
MPGN
What disease process? IgG, IgA, and C3 in a mesangial pattern
IgA Nephropathy
What disease process? Immune complex deposition in the walls of vessels
Cryoglobulinemia
What disease process? Linear immunofluorescence
anti-GBM disease (Goodpasture disease)
What disease process? May present with gross hematuria with onset of a viral illness
IgA Nephropathy
What disease process? Membranoproliferative pattern with subendothelial immune deposits
Cryoglobulinemia
What disease process? Most common in men 15-35 years of age
IgA Nephropathy
What disease process? Most common type of acute glomerulonephritis
IgA Nephropathy
What disease process? Most patients resolve spontaneously
Post-Infectious Glomerulonephritis
What disease process? MPGN with a predominance of IgA immune deposits
IgA Nephropathy
What disease process? Neutrophil infiltration and extensive crescent formation
anti-GBM disease, pauci-immune vasculitis
