Renal III: Nephrotic Syndrome Flashcards
Additional clinical features/complications of Nephrotic Syndrome (4)
Increased coagulability, increased infections, poor growth in children, protein malnutrition
Characteristics of Nephrotic Syndrome
Proteinuria, hyperlipidemia, edema, lipiduria, hypoalbuminemia
Which idiopathic Nephrotic Syndrome? Adult male predominance
Membranous Nephropathy
Which idiopathic Nephrotic Syndrome? Associated with abnormalities in suPAR
FSGS
Which idiopathic Nephrotic Syndrome? Associated with chronic infection, cirrhosis, and systemic connective tissue disease
Membranoproliferative Nephropathy
Which idiopathic Nephrotic Syndrome? Associated with complement disorders
Membranoproliferative Nephropathy Type II
Which idiopathic Nephrotic Syndrome? Associated with HCV infection
Membranoproliferative Nephropathy Type I
Which idiopathic Nephrotic Syndrome? Associated with Hepatitis B
Membranous Nephropathy
Which idiopathic Nephrotic Syndrome? Associated with heroin use
FSGS
Which idiopathic Nephrotic Syndrome? Associated with HIV infection
FSGS
Which idiopathic Nephrotic Syndrome? Associated with Hodgkin lymphoma
Minimal Change Disease
Which idiopathic Nephrotic Syndrome? Associated with Lupus
Membranous Nephropathy
Which idiopathic Nephrotic Syndrome? Associated with NSAIDs
Minimal Change Disease
Which idiopathic Nephrotic Syndrome? Associated with plasma cell neoplasms
Membranoproliferative Nephropathy
Which idiopathic Nephrotic Syndrome? Associated with solid tumors of breast, lung, and GI tract
Membranous Nephropathy
Which idiopathic Nephrotic Syndrome? GBM replaced by dense C3 deposits
Membranoproliferative Nephropathy Type II
Which idiopathic Nephrotic Syndrome? Good response to steroid therapy
Minimal Change Disease
Which idiopathic Nephrotic Syndrome? Immune complex deposits in subepithelial space
Membranous Nephropathy
Which idiopathic Nephrotic Syndrome? Lobular and mesangial proliferation with GBM thickening
Membranoproliferative Nephropathy
Which idiopathic Nephrotic Syndrome? Most common cause of idiopathic nephrotic syndrome in adults
Membranous Nephropathy
Which idiopathic Nephrotic Syndrome? Most common in African Americans
FSGS
Which idiopathic Nephrotic Syndrome? Most common in young adults
FSGS
Which idiopathic Nephrotic Syndrome? Most common nephrotic syndrome in children
Minimal Change Disease
Which idiopathic Nephrotic Syndrome? Most commonly associated with concurrent nephritic syndrome
Membranoproliferative Nephropathy
Which idiopathic Nephrotic Syndrome? Most commonly due to antibodies to phospholipase 2 (PLA-2)
Membranous Nephropathy
Which idiopathic Nephrotic Syndrome? Normal light microscopy
Minimal Change Disease
Which idiopathic Nephrotic Syndrome? Primarily affects adolescents
Membranoproliferative Nephropathy
Which idiopathic Nephrotic Syndrome? Prolonged steroid therapy in only half of patients
FSGS
Which idiopathic Nephrotic Syndrome? Subendothelial and mesangial deposits of immune complexes
Membranoproliferative Nephropathy Type I
Which idiopathic Nephrotic Syndrome? Thickening of glomerular basement membrane with normal cellularity
Membranous Nephropathy
Which idiopathic Nephrotic Syndrome? Twice as common in male children
Minimal Change Disease
Which pathology? Amorphous pink material in glomeruli and vessels; positive Congo red stain with apple green birefringence
Amyloidosis
Which pathology? Isolated low C4 complement levels
Hepatitis C-related MPGN
Which pathology? Most common cause of nephrotic syndrome in adults
Diabetic Nephropathy
Which pathology? Pathology pattern of nodular sclerosis and GBM thickening, treat with glucose control
Diabetic Nephropathy
