Renal III: Nephrotic Syndrome

Question 1

Additional clinical features/complications of Nephrotic Syndrome (4)

Answer 1

Increased coagulability, increased infections, poor growth in children, protein malnutrition

Question 2

Characteristics of Nephrotic Syndrome

Answer 2

Proteinuria, hyperlipidemia, edema, lipiduria, hypoalbuminemia

Question 3

Which idiopathic Nephrotic Syndrome? Adult male predominance

Answer 3

Membranous Nephropathy

Question 4

Which idiopathic Nephrotic Syndrome? Associated with abnormalities in suPAR

Answer 4

FSGS

Question 5

Which idiopathic Nephrotic Syndrome? Associated with chronic infection, cirrhosis, and systemic connective tissue disease

Answer 5

Membranoproliferative Nephropathy

Question 6

Which idiopathic Nephrotic Syndrome? Associated with complement disorders

Answer 6

Membranoproliferative Nephropathy Type II

Question 7

Which idiopathic Nephrotic Syndrome? Associated with HCV infection

Answer 7

Membranoproliferative Nephropathy Type I

Question 8

Which idiopathic Nephrotic Syndrome? Associated with Hepatitis B

Answer 8

Membranous Nephropathy

Question 9

Which idiopathic Nephrotic Syndrome? Associated with heroin use

Answer 9

FSGS

Question 10

Which idiopathic Nephrotic Syndrome? Associated with HIV infection

Answer 10

FSGS

Question 11

Which idiopathic Nephrotic Syndrome? Associated with Hodgkin lymphoma

Answer 11

Minimal Change Disease

Question 12

Which idiopathic Nephrotic Syndrome? Associated with Lupus

Answer 12

Membranous Nephropathy

Question 13

Which idiopathic Nephrotic Syndrome? Associated with NSAIDs

Answer 13

Minimal Change Disease

Question 14

Which idiopathic Nephrotic Syndrome? Associated with plasma cell neoplasms

Answer 14

Membranoproliferative Nephropathy

Question 15

Which idiopathic Nephrotic Syndrome? Associated with solid tumors of breast, lung, and GI tract

Answer 15

Membranous Nephropathy

Question 16

Which idiopathic Nephrotic Syndrome? GBM replaced by dense C3 deposits

Answer 16

Membranoproliferative Nephropathy Type II

Question 17

Which idiopathic Nephrotic Syndrome? Good response to steroid therapy

Answer 17

Minimal Change Disease

Question 18

Which idiopathic Nephrotic Syndrome? Immune complex deposits in subepithelial space

Answer 18

Membranous Nephropathy

Question 19

Which idiopathic Nephrotic Syndrome? Lobular and mesangial proliferation with GBM thickening

Answer 19

Membranoproliferative Nephropathy

Question 20

Which idiopathic Nephrotic Syndrome? Most common cause of idiopathic nephrotic syndrome in adults

Answer 20

Membranous Nephropathy

Question 21

Which idiopathic Nephrotic Syndrome? Most common in African Americans

Answer 21

FSGS

Question 22

Which idiopathic Nephrotic Syndrome? Most common in young adults

Answer 22

FSGS

Question 23

Which idiopathic Nephrotic Syndrome? Most common nephrotic syndrome in children

Answer 23

Minimal Change Disease

Question 24

Which idiopathic Nephrotic Syndrome? Most commonly associated with concurrent nephritic syndrome

Answer 24

Membranoproliferative Nephropathy

Question 25

Which idiopathic Nephrotic Syndrome? Most commonly due to antibodies to phospholipase 2 (PLA-2)

Answer 25

Membranous Nephropathy

Question 26

Which idiopathic Nephrotic Syndrome? Normal light microscopy

Answer 26

Minimal Change Disease

Question 27

Which idiopathic Nephrotic Syndrome? Primarily affects adolescents

Answer 27

Membranoproliferative Nephropathy

Question 28

Which idiopathic Nephrotic Syndrome? Prolonged steroid therapy in only half of patients

Answer 28

FSGS

Question 29

Which idiopathic Nephrotic Syndrome? Subendothelial and mesangial deposits of immune complexes

Answer 29

Membranoproliferative Nephropathy Type I

Question 30

Which idiopathic Nephrotic Syndrome? Thickening of glomerular basement membrane with normal cellularity

Answer 30

Membranous Nephropathy

Question 31

Which idiopathic Nephrotic Syndrome? Twice as common in male children

Answer 31

Minimal Change Disease

Question 32

Which pathology? Amorphous pink material in glomeruli and vessels; positive Congo red stain with apple green birefringence

Answer 32

Amyloidosis

Question 33

Which pathology? Isolated low C4 complement levels

Answer 33

Hepatitis C-related MPGN

Question 34

Which pathology? Most common cause of nephrotic syndrome in adults

Answer 34

Diabetic Nephropathy

Question 35

Which pathology? Pathology pattern of nodular sclerosis and GBM thickening, treat with glucose control

Answer 35

Diabetic Nephropathy