Renal Histology Flashcards
Where are the kidneys located in the body?
Retroperitoneal, T12-L3
What is the normal weight range of the kidney?
115-170g (M>F)
What are the normal dimensions of the kidney?
11-12 x 5-7.5 x 2.5-3 cm
The mesonephric duct comes in contact with the ___ and grows cranially as the ___.
Cloaca; ureteric ubd
The ureteric bud and ___ reciprocally induce growth, forming kidneys.
Metanephros
What is the hilum?
The part of the kidney with the renal pelvis, ureter, renal artery, and renal vein
Describe renal blood supply.
Renal artery branches into interlobar arteries (either side of medullary pyramid) which branches into arcuate arteries (between cortex and medulla) which branch into interlobular arteries which branch into afferent arterioles
What are the two components of the glomerulus in a paraffin section?
Bowman’s capsule and the glomerular tuft
What is the mesangium?
Cells and matrix that regulate blood flow/filtration and provide structural support
What are the components of the glomerulus?
- Network of capillaries
- Mesangium
- Endothelium
- Basement membrane
- 2 layers of epithelium
What are the parts of the glomerular basement membrane?
Lamina rara externa, lamina densa, lamina rara externa
Proteinuria tends to be caused by a loss of what two things?
Charge and slit membranes
Hematuria tends to be caused by a loss of what two things?
Integrity and structure
What is the functional and structural unit of the kidney?
Nephron
Distinguish between proximal and distal tubules on histology.
Proximal: pink cytoplasm, narrower lumen
Distal: cuboidal epithelium, wider
