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MHD 1 > Block 6 Histology > Flashcards

Block 6 Histology Flashcards

1
Q

How does the BM change with age?

A

Older patients have less cellularity and more fat

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2
Q

What are the 4 types of myeloid cells?

A
  1. Neutrophils
  2. Basophils
  3. Eosinophils
  4. Monocytes/macrophages
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3
Q

What are the 3 granulocytes?

A
  1. Neutrophils
  2. Basophils
  3. Eosinophils
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4
Q

What are the other hematopoietic cells?

A
  1. Erythrocytes
  2. Megakaryocytes
  3. Lymphoid cells (B and T cells)
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5
Q

Discuss the maturation of a neutrophil cell.

A
  1. Myeloblast
  2. Myelocyte (large cell, round nucleus)
  3. Late myelocyte/Early metamyelocyte (nucleus begins to indent)
  4. Metamyelocyte (indented nucleus)
  5. Band cell (thin nucleus)
  6. Segmented (mature) neutrophil
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6
Q

How are band cells identified?

A

Indented nucleus shaped like a horseshoe

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7
Q

Which WBCs have bilobed nuclei and bright pink granules in the cytoplasm?

A

Eosinophils

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8
Q

Which WBCs have blue/purple cytoplasm filled with granules that obscure the nucleus?

A

Basophils

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9
Q

Which WBCs are relatively small, about the size of RBCs?

A

Lymphocytes

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10
Q

Which WBCs have an indented nucleus (kidney bean shaped) and grey/blue cytoplasm?

A

Monocyte

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11
Q

Which WBCs have multilobed nuclei?

A

Neutrophils

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12
Q

Which WBCs have eccentrically placed nuclei with clock face chromatin - clumped and restricted to periphery of nucleus?

A

Plasma cells

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13
Q

What are the primary (central) lymphoid organs and what do they contain?

A

Bone marrow and thymus; immature lymphoid cells

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14
Q

What are the secondary (peripheral) lymphoid organs and what do they contain?

A

Lymph nodes, spleen, mucosal associated lymphoid tissue (MALT); mature lymphoid cells

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15
Q

Which part of the thymus has more T-cells? More epithelial cells?

A

More T-cells: cortex

More epithelial cells: medulla

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16
Q

What are concentric structures of degenerated epithelial cells seen in the thymic medulla?

A

Hassall’s corpuscle

17
Q

What is contained in the cortex of the lymph node?

A

Follicles

18
Q

What is contained in the medulla of the lymph node?

A

Medullary sinuses and cords

19
Q

What is the difference between a primary and secondary follicle in the lymph node?

A

Primary: mature, naive B cells
Secondary: germinal center, site of B cell proliferation

20
Q

What is the dark zone surrounding the lymph node follicle/germinal center?

A

Mantle zone

21
Q

Describe the white pulp of the spleen.

A

Peri-arterial lymph sheath filled with T-cells surround arterioles in the spleen

22
Q

Describe the red pulp of the spleen.

A

Cellular cords surround open sinuses and contain macrophages

MHD 1 (58 decks)

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