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First Aid Renal > Renal Cancer > Flashcards

Renal Cancer Flashcards

1
Q

Risk factors of Renal Cell Carcinoma

A

Smoking and obesity

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2
Q

How Renal cell carcinoma metastasizes

A

renal vein to IVC to lung&bone; hematogenously

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3
Q

Chromosome affected in renal cell carcinoma

A

Chromosome 3; loss of VHL (3p) tumor suppressor

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4
Q

How renal cell carcinoma presents

A

hematuria, palpable mass, secondary polycythemia, flank pain, fever and weight loss
Micro: polygonal clear cells cells

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5
Q

Tx of renal cell carcinoma

A

resection if localized; immunotherapy or trgeted therapy if advanced (not chemo or radiation)

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6
Q

benign epithelial cell tumor of kidney; large eosinophilic cells with abundant mitochondria

A

renal Oncocytoma

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7
Q

Tx of Renal Oncocytoma

A

Nephrectomy

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8
Q

Most common renal malignancy of early childhood

A

Wilms tumor; nephroblastoma

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9
Q

Huge palpable flank mass and/or hematuria. HTN in childhood

A

Wilms tumor

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10
Q

“loss of function” mutations of WT1 or WT2 on chromosome 11

A

wilms tumor

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11
Q

Beckwith-Wiedemann Syndrome or WAGR

A

Wilms tumor; Aniridia; GU malformation; mental Retardation

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12
Q

Kidney tumor composed of blastema

A

Wilms tumor

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13
Q

Most common tumor of urinary tract system

A

Transitional Cell Carcinoma

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14
Q

Causes of Transitional cell carcinoma

A

Phenacetin, Smoking, Aniline dyes, and cyclophosphamide

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15
Q

Papillary Pathway for Transitional Cell carcinoma

A

Papillary growth with fibrovascular core with epithelium over it.
Tumor starts low grade then high grade then invades

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16
Q

Flat Pathway for Transitional Cell Carcinoma

A

starts high grade and invades; associated with early p53 mutations

17
Q

Chronic irritation of urinary bladder

A

SCC of bladder

18
Q

young, middle eastern dude with painless hematuria

A

Schistosoma haematobium (SCC of bladder)

19
Q

SCC of bladder risks

A

chronic cystitis, smoking, chronic nephrolithiasis

20
Q

Malignant proliferation of glands in the bladder

A

Adenocarcinoma of bladder

21
Q

Adenocarcinoma of bladder arises from

A

Urachal remnant; cystitis glandularis; exstrophy

22
Q

fetal bladder to yolk sack connection

A

Urachus

First Aid Renal (14 decks)

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