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First Aid Renal > Glomerular Diseases > Flashcards

Glomerular Diseases Flashcards

1
Q

Focal

A

<50% of glomeruli are involved

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2
Q

Diffuse

A

> 50% of glomeruli are involved

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3
Q

Proliferative

A

Hypercellular glomeruli

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4
Q

Membranous

A

Thickening of glomeruli basement membrane

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5
Q

Primary Glomerular Disease

A

Involves only glomeruli, a primary disease of the kidney

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6
Q

Secondary Glomerular Disease

A

Involves glomeruli and other organs, Ex. SLE and diabetic nephropathy

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7
Q

List of nephritic syndrome

A

acute poststreptococcal glomerulonephritis; rapidly progressive glomerulonephritis; Berger Dx (IgA glomerulonephropathy); Alport

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8
Q

List of nephrotic syndrome

A

Focal segmental glomerulosclerosis; membranous nephropathy; minimal change disease; amyloidosis; Diabetic Glomerulonephropathy

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9
Q

Both Nephritic and Nephrotic

A

Diffuse proliferative glomerulonephritis & Membranoproliferative glomerulonephritis

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10
Q

Massive prOteinuria (>3.5g/day) frothy urine, hyperlipidemia, fatty casts, edema

A

NephrOtic Syndrome

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11
Q

Segmental sclerosis and hyalinosis

A

Focal Segmental Glomerulosclerosis

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12
Q

Effacement of foot processes (name 2)

A

Focal Segmental Glomerulosclerosis & Minimal Change Disease

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13
Q

Blacks & Hispanics, HIC, sickle cell, heroin-abuse, massive obesity, IFN tx

A

Focal Segmental Glomerulosclerosis

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14
Q

Diffuse capillary and GBM thickening on light microscopy

A

Membranous Nephropathy

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15
Q

Immune complex deposition. Nephrotic presentation of SLE.

“spike and dome”

A

Membranous Nephropathy

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16
Q

Most common cause of primary nephrotic syndrome in Whites

A

Membranous Nephropathy

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17
Q

Antibody to Phospholipase A2 receptor; NSAIDs, penicillamine, HBV, HCV, SLE, or solid tumor

A

Membranous Nephropathy

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18
Q

Normal glomeruli, may be associated with Hodgkin Lymphoma (reed-sternberg cytokine mediated)

A

Minimal Change Disease

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19
Q

Nephrotic Syndrome triggered by recent infection, immunization, or immune stimulus

A

Minimal Change Disease

20
Q

Excellent response to steroids

A

Minimal Change Disease

21
Q

Congo red stain with apple-green biregringence

A

Amyloidosis

22
Q

Tram-track appearance due to GBM splitting caused by mesangial ingrowth

A

Type I membranoproliferative glomerulonephritis

23
Q

Intramembranous immune complex deposits “dense deposits”

A

Type II membranoproliferative glomerulonephritis

24
Q

MPGN Type I is associated with

A

HepB and C

25
Q

MPGN Type II is assoicated with

A

C3 nephritic factor which stabilizes C3 nephritic factor decreasing C3 serum

26
Q

Kimmelstiel-Wilson lesion

A

Diabetic Glomerulonephropathy, eosinophilic nodular glomerulosclerosis

27
Q

Nonenzymatic glycosylation of efferent arterioles

A

Increases GFR and causes mesangial expansion; associated with diabetic glomerulonephropathy

28
Q

Inflammatory process of nephrons that leads to hematuria and RBC casts. Associated with azotemia, oliguria, HTN, proteinuria <3.5g/day

A

Nephritic Syndrome

29
Q

Starry sky granular appearance and lumpy bumpy IgG, IgM, and C3 deposition along GBM and mesangium

A

Acute Post-streptococcal glomerulonephritis

30
Q

Subepithelial Immune Complex Humps

A

Acute Post-streptococcal glomerulonephritis

31
Q

~2weeks after group A streptococcal infection

A

Acute Post-streptococcal glomerulonephritis

32
Q

Acute Post-streptococcal glomerulonephritis hypersensitivity

33
Q

Peripheral and periorbital edema, dark urine and HTN

A

Acute Post-streptococcal glomerulonephritis

34
Q

anti-DNase B titers and decreases complement levels

A

Acute Post-streptococcal glomerulonephritis

35
Q

crescent moon

A

rapidly progressive glomerulonephritis

36
Q

Goodpasture syndrome

A

looks like rapidly progressive glomerulonephritis; type II HS

37
Q

Hematuria and Hemoptysis

A

Goodpasture Syndrome; RPGN

38
Q

Wire looping of capillaries

A

Diffuse proliferative glomerulonephritis

39
Q

Subendothelial and sometimes intramembranous IgG-based immune complexes often with C3 deposition

A

Diffuse proliferative glomerulonephritis

40
Q

IgA-based IC deposits in mesangium seen with henoch-Schonlein purpura

A

IgA nephropathy (Berger Disease)

41
Q

episodic hematuria with RBC casts; often with flares of URI or acute gastroenteritis

A

IgA nephropathy (Berger Disease)

42
Q

Muated Type IV collagen

A

Alport Syndrome

43
Q

Glomerulonephritis, deafness, and less commonly, eye problems

A

Alport Syndrome

44
Q

MPO-ANCA

A

Microscopic polyangiitis

45
Q

PR3-ANCA

A

Granulomatosis with polyangiitis (Wegener)

46
Q

c-ANCA

A

Granulomatosis with polyangiitis (Wegener)

First Aid Renal (14 decks)

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