Renal 7th lecture Flashcards
________ - Fluid in the renal tubules
that becomes urine
Filtrate
_________- Substances move
from the filtrate into the blood
Reabsorption
Secondary active transporters or
cotransporters facilitate Na+
reabsorption with cotransport of
glucose and amino acids.
_____________- Waste products move
from the blood into the filtrate
Secretion
Excretion
= Filtration – Reabsorption + Secretion
Tubular cell membrane
__________ (= Luminal)
Cell membrane oriented
towards the lumen
Apical
_______________
Cell membrane oriented away the lumen
Basolateral
_______________: to maintain the high medullar osmolarity to concentrate urine
Urea reabsorption
Thin descending limb loop of Henle and thick ascending loop of Henle
Concentration of the urine
H2O > NaCl in lumen
Normally, how much glucose, amino acid, lactate, and
water-soluble vitamins are reabsorbed after filtration?
Where is the primary location of the reabsorption?
A. ~100%, PCT
B. ~70%, PCT
C. ~100%, DCT
D. ~70%, DCT
Sodium K+/ATPase in the nephron
It maintain a low intracellular [Na+], establishing an electrochemical gradient for Na+
Na+/K+-ATPase in the ____________ membrane transports Na+ into the interstitial spaces and K+ into the cell, establishing an electrochemical gradient for Na+
basolateral
Proximal Convoluted Tubule (PCT)= Proximal Tubule
How about NH3(ammonia) ? It can cross the membrane! Once outside, it becomes ________
NH4+(ammonium)
Which of the following substances is important for the
kidney to reabsorb due to its role as a crucial buffer?
A. Bicarbonate (HCO3-)
B. Na+
C. K+
D. H+
How is the charged HCO3- reabsorbed?
Transformed to CO2
_________________ (CA) catalyzes the dehydration of H2CO3 (carbonic acid) to CO2 (carbon dioxide) at the luminal membrane and rehydration of CO2 to H2CO3 in the cytoplasm
Carbonic anhydrase
Proximal tubule
NaHCO3 (sodium bicarbonate) reabsorption and acid secretion by _______________ (CA)
Carbonic anhydrase
______catalyzes the dehydration of H2CO3 (carbonic acid) to CO2 at the luminal membrane and rehydration of CO2 to H2CO3 in the cytoplasm
CA
