Carbonic anhydrase Flashcards
Where do carbonic anhydrase inhibitors work?
PCT (Proximal convoluted tubule)
Where do loop diuretics work?
Loop diuretics
Where do thiazides work?
distal convoluted tubule
Where do K+sparing diuretics work?
collecting duct
Drugs that modify salt excretion
Carbonic anhydrase inhibitors (acetazolamide)
__________ diuretics (furosemide)
____________(hydrochlorothiazide)
K+ sparing diuretics (spironolactone)
loop diuretics
thiazides
Drugs that modify water excretion
ADH antagonists (conivaptan) and ADH agonists(desmopressin)
ADH antagonists
ADH agonists
Carbonic Anhydrase (CA) – Net effect
Net Ion Movement
IN: _______, ______
OUT: H+
Na+, HCO3-
Carbonic Anhydrase (CA) creates a ______intracellular Na+ concentration, which drives secondary active transport mechanisms
low
CA catalyzes the dehydration of H2CO3 to CO2 at the luminal membrane and rehydration of CO2 to H2CO3 in the cytoplasm
CA (carbonic anyhydrase)
Carbonic anhydrase (CA) inhibitors
By Blocking CA, inhibitors decrease NaHCO3 reabsorption and increase ______,_______ reabsorption
H+, Cl-
How is inhibition of HCO3- reabsorption related to the reabsorption of Na+ and water? less absorption of _________
NHE3
Carbonic anhydrase (CA) inhibitors)
Carbonic anhydrase (CA) in ________
Other functions of CA
Production of aqueous humor in ciliary
body of the eye →regulation of intraocular pressure (IOP)
1.CSF formation → regulation of CSF pH
and volume
PCT
Carbonic anhydrase
Prototype – Acetazolamide (_________)
↳ Dichlorphenamide
↳ Dorzolamide (eye drops)
Diamox
CA Inhibitors - MOA
Inhibit the enzymatic activity of CA
