Renal 6 Flashcards

1
Q

Where does water reabsorbtion occur

A

In the collecting duct

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2
Q

AVP secretion happens due to

A

Increased osmolarity
Decreased blood volume
Decreased Blood pressure

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3
Q

What creates the hyperosmotic onterestinium in medulla

A

Countercurrent exhange system
Urea

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4
Q

Countercurrent Exchnage system

A

to reduce heat loss

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5
Q

two parts of renal countercurrent exchange system

A

Countercurrent multiplier
Countercurrent exchanger

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6
Q

Loop of henle

A

Countercurrent multplier

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7
Q

Peritubular capillaries (Vasa recta)

A

Countercurrent exchanger

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8
Q

Countercurrent multiplier

A

the descending limb has a lot of aquaporin channels allowing water to follow its concentration gradient into the hyperosmotic interstitinum
The ascending henle limb of the loop actively trasports Na Cl and K into the interstitinum

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9
Q

What are responsible for the high osmolarity deep in meduula

A

Nephron and vasa recta of juxtamedullary nephrons

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10
Q

There is a ton of active transport

A

In the ascending limb

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11
Q

How does urea contribute to the osmolarity of the medullary interstitium

A

Creates a recycling loop
About half the solute in the meduula interstinium is urea

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12
Q

Increases Osmolarity (NaCl)

A

Vasopresson secreted and Thirst
Blood pressure goes up, ECF volume goes up

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13
Q

Where is more sodium excereted

A

Urine

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14
Q

Hormone for Sodium Balance

A

Renin Angiotensin aldosterone system

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15
Q

Where does this hormone target

A

Last third of the distal tubule and the portion of the collecting duct

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16
Q

If potassium is high

A

Blood pressure is low and more aldosterone is secreted

17
Q

Addiotional modifiers of aldosterone release

A

Increased osmolarity during dehydration
Abnormally large drops in plasma Na+

18
Q

Renin Angiotensin System (RAS)

A

A multistep pathway for maintaining blood pressure

19
Q

Three stimuli of renin secretion

A

Low blood pressure in renal arterioles causes granular cells to secrete renin
Sympathetic neurons by CVCC when blood pressure decreases terminate on granular cells and stimulate renin secretion
Paracrine feedback from macula densa cells signal to the granular cells to secrete renin

20
Q

What is role of renin

A

Converts an angiotensinogen into angiotensin 1 and then it converts to angiotensin 2 that travels to adrenal cortex and stimulates production of aldosterone

21
Q

Atrial Natriuretic peptide (ANP)

A

Causes loss of Na+ and Water
When blood volume and pressure is high
Opposite effects of angiotensin 2

22
Q

Where is Pottasium Reabsorbed

A

Proximal Tubule ans ascending limb of loop of henle

23
Q

Potassium balance is altered by

A

Secretion

24
Q

Where is pottasium secreted

A

Distal tubule and cortical collecting duct

25
Q

What controls pottasium secretion

A

Aldosterone

26
Q

Low pottasium means

A

Low aldosterone and less pottasium secretion

27
Q

Hypokalemia

A

Casues muscle weakness

28
Q

Hyperkalemia

A

Hyperexcitability

29
Q

ANG 2 does

A

Increased CO
Increased Na+ Reabsorbtion
Peripheral Vasoconstriction
Thirst

30
Q

Thirst is controlled by

A

Hypothalamus

31
Q

Barorecptors

A

Decrease in blood pressure

32
Q

Avoidance Behaviours

A

Helps prevent Dehydration

33
Q
A