GI 2 and 3 Flashcards
Digestion
Chemical and mechanical breakdown of food into absorbable units
Secretion
Movement of material from cells of the lumen or ECF
Absorbtion
Movement of material from GI lumen to ECF
mobility
Movement of material through the GI tract as a result of muscle contraction
Challenges of the digestive system
Avoiding autodigestion
Defense
Maintaining mass balance
Avoiding Autodigestion
Breaking food down into small enough molecules to be absorbed without digesting the cell of the GI tract
Defense
Absorbing water and nutrients while preventing bacteria, viruses and other pathogens from entering the body.
mechanisms of defense
Mucus, digestive enzymes, acid and the largest collection of lymphoid tissue
Fluid secretions
Water, Digestive Enzymes and Mucus
Water
Ions are transported from ECF into the Lumen
Creates osmotic gradient for water movement
Digestive Enzymes
- Exocrine glands (Salivary and pancreas)
- Epithelial cells in stomach and small intestine
Zymogen
Inactive enzymes
Mucus
Viscous glycoprotein (mucins) secretions that protect GI cells and lubricate the contents
Most fluid secretion fascilitates
Digestion
Two purposes of motility
- Moves food from mouth to anus
- Mechanically mixing food breaks it into uniformly small particles
Muscles involved in motility
Skeletal and Smooth Muscle
How are smooth muscles of motility modifies
Chemical and mechanical input from nerves
Hormones and paracrine signals
Phasic smooth muscle
Cycle of contraction and relaxation
In esophagus, stomach and large intestile
Slow wave
Modified by chemical input from neurons, hormones and paracrine signals
Where do slow waves likely orginate from
Interstitial cells of cajal (icc)
ICC
Modified smooth muscle cells serving as the pacemaker for slow wave activity
Migrating Motor Complex
Starts in stomach and passes from section to section terminating at the ilum (Through the small intestine)
Inbetween meals.
Sweeps food remnants and bacteria out of the upper GI tract and into the large intestine
Peristaltic Contractions
During or following a meal
Circular layer of smooth muscle: Contracts responsible for forward movement
Segmental Contractions
Are responsible for mixing
Circular and longitudinal contractions