Receptors

Question 1

B1 receptor

Answer 1

NE legates—> cardiac stimulation (increased HR/BP/Contractility)
Renin release
Lipolysis

Question 2

B2 receptor

Answer 2

Epi ligates—> bronchodilation, vasodilation, glycogenolysis

Question 3

Beta Blockade

Answer 3

B1: bradycardia, renin suppression, reduced FA synthesis

B2: bronchospams, vasoconstriction, reduced energy/hypoglycemia

**cardioselective attempts to only block B1 so as not to cause B2 blocking effects (not very effective)

**Partial agonists try to do the same, not very effective either

**Membrane stabilizing: antiarrhythmic? Antiplatelet?

Question 4

Should BB be stopped before surgery

Answer 4

NO!!! Can cause rebound HTN d/t upregulation of B receptors

Question 5

Should BB be started on the day of surgery?

Answer 5

NO! Doesn’t work, needs to be started weeks ahead of time.

Pts do worse!