General Pharm

Question 1

Agonist

Answer 1

Bind to receipt and stimulate the function that receptor serves

Question 2

Antagonist

Answer 2

Bind to receptor and block the body from doing the function

Question 3

Competitive binding

Answer 3

Reversible, drug will stay on receptor as long as drug is in higher concentration than body’s own chemicals. Once drug gets low enough body’s own will take back over

Question 4

Non competitive binding

Answer 4

Non reversible (I.e. aspirin binds to platelets and never leaves. In order to resume normal functioning the body has to make new platelets)

Question 5

Bonds (strongest to least)

Answer 5

Covalent, ionic, hydrogen, hydrophobic, Van dear walks

Question 6

Therapeutic index

Answer 6

LD50/ED50 (median lethal dose/effective dose)

Question 7

Therapeutic window

Answer 7

Point where you can get effect without much toxicity (minimum toxic concentration/minimum effective dose)

Question 8

pKa

Answer 8

Ionization constant of chemical compound. pH at which the drug will exist as 50% ionized/non-ionized

PH-pKa=0 ratio=50%
PH-pKa=0.5 ratio=75/25%
Ph-pKa=1or> ratio=99/1%

Acid in acid=nonionized
Bas in base=nonionized
Acid in basic=ionized
Base in acid=ionized

Question 9

Number of half lives to eliminate drug

Answer 9

4