PNS/SNS

Question 1

Metabolism of catecholamine

Answer 1

Phenylalanine—> Tyrosine*** —>DOPA —> Dopamine —> Norepinephrine —> Epinepherine (primarily synthesized in the adrenal medulla)

**conversion of tyrosine to DOPA by tyrosine hydroxylase is inhibited by increased NE synthesis (negative feedback). Also point of drug inhibition

Question 2

MAO and COMT

Answer 2

Breakdown catecholamine in nerves (MAO) or synapse (COMT)

Question 3

Long preganglionic/short post ganglionic fibers

Answer 3

PNS

Question 4

Preganglionic release ACh, postganglionic release NE

Answer 4

SNS

Question 5

Which nerve accommodates majority of PNS function

Answer 5

Vagus nerve

Question 6

Muscarinic Receptors act in this Nervous System

Answer 6

PNS

Question 7

SNS MOA

Answer 7

NE stored and packaged in vesicles —> AP stimulates release of NE —>release into synapse —> goes to post-synaptic receptor —> sympathetic response —> feedback to presynaptic A2 receptors —> negative feedback —> decrease catecholamine release