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Reproductive & Sexual Health > Radiotherapy and Chemotherapy in Gynaecological cancer > Flashcards

Radiotherapy and Chemotherapy in Gynaecological cancer Flashcards

1
Q

Which proteins are involved in HPV 16 AND 18 cervical cancer?

A

E6 and E7

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2
Q

What are the risk factors for cervical cancer ?

A
  • Smoking
  • Age of onset of intercourse
  • High Risk male
  • OCP
  • Multiple partners
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3
Q

Describe stage 1a of cervical cancer?

A

Microscopic

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4
Q

Describe stage 1b of cervical cancer?

A

Visible lesion

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5
Q

Describe stage 2a of cervical cancer?

A

Vaginal involvement

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6
Q

Describe stage 2b of cervical cancer?

A

Parametrial involvement

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7
Q

Describe stage 3 of cervical cancer?

A

Lower vagina or pelvic sidewall

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8
Q

Describe stage 4 of cervical cancer?

A

Bladder/rectum or metastases

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9
Q

What is the treatment for cervical cancer?

A
  • Surgery
    • LLETZ
    • fertility sparing
    • Wertheim
  • Radiotherapy
  • Chemotherapy
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10
Q

What is LLETZ?

A

Large loop excision of transformation zone

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11
Q

What is wertheim?

A

Radical hysterectomy

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12
Q

Describe radiotherapy treatment of cervical cancer?

A

High energy x-rays

Targeted to include tumour +/- nodes

External Beam

Brachytherapy

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13
Q

What is bracytherapy?

A

It places radioactive sources inside the patient to kill cancer cells and shrink tumors.

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14
Q

What kind of chemotherapy can be offered in cervical cancer?

A
  • neoadjuvant
  • concomittant
  • palliative
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15
Q

What chemotherapy drugs are used in cervical cancer?

A

Cisplatin

  • 40mg/m2 weekly

Carboplatin/paclitaxol

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16
Q

What is used in brachytherapy?

A

Intrauterine tube

Ovoids (colpostats)

Ring applicator

17
Q

What is the mainstay of endometrial cancer treatment?

18
Q

What are the aetiological factors involved in endometrial cancer?

A

Obesity

Oestrogens- HRT, tamoxifen

Genetic- HNPCC

19
Q

How does endometrial cancer commonly present

A

Post Menopausal Bleeding

20
Q

What is the treatment of endometrial cancer?

A

TAH BSO washings

Controversy over role of lymphadenectomy

21
Q

What is TAH BSO

A

total abdominal hysterectomy with bilateral salpingo-oophorectomy.

22
Q

What radiotherapy can be performed for endometrial cancer

A

Adjuvant radiotherapy

  • vault brachytherapy
  • external beam

Reproductive & Sexual Health (54 decks)

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