Pre-term Infant Flashcards

1
Q

Over __% of deaths in childhood occur in the 1st year of life, and are strongly influenced by ________ delivery and low birth _____. With risk factors including _________ ___, _______ and ________ circumstances,

A

Over 50% of deaths in childhood occur in the 1st year of life, and are strongly influenced by pre-term delivery and low birth weight. With risk factors including maternal age, smoking and disadvantaged circumstances,

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2
Q

Which babies are more at risk of death?

A

Black or black british

Asian or asian british

Teenage mothers

Mothers over 40

Mothers living in poverty

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3
Q

__ _______ babies are born preterm every year

A

15 million

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4
Q

Why is the number of preterm babies increasing?

A
  • Increased maternal age
  • Increasing rate of pregnancy-related complications
  • greater use of infertility treatments
  • more cesearean deliveries before term
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5
Q

What are the causes of preterm birth?

A
  • spontaenous preterm labour
  • preterm rupture of membranes
  • multiple pregnancy
  • pregnancy associated hypertension
  • cervical incompetence/uterine malformation
  • antepartum haemorrhage
  • IUGR
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6
Q

What are the risk factors for preterm birth

A
  • > 2 preterm deliveries increases the risk of another premature baby by 70%
  • abnormally shaped uterus increases the risk of giving birth by 19%
  • women are 9 times more likely to give birth early if they have a multiple pregnancy
  • interval of <6 months between pregnancies
  • concieving through IVF
  • smoking, drinking alcohol and using ilicit drugs
  • poor nutrition, chronic conditions (hypertension, diabetes), multiple miscarriages or abortions
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7
Q

What is the difference in managing a preterm baby?

A
  • need more help to stay warm
  • have more fragile lungs
  • don’t breathe effectively
  • have fewer reserves
  • delay cord clamping if possible
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8
Q

How are preterm babies best kept warm?

A

Place them while still wet in a suitable plastic bag and later under a radiant heater

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9
Q

What are the common problems of prematurity?

A
  • temperature control
  • feeding/nutrition
  • sepsis
  • system immaturity/dysfunction
    • RDS
    • PDA
    • IVH
    • NEC
  • others; metabolic, ROP (retinopathy of prematurity)
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10
Q

Why is thermal regulation ineffective in premature babies?

A
  • Low BMR
  • minimal muscular activity
  • subcutaenous fat insulation is negligible
  • high ratio of surface area to body mass
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11
Q

What are the methods of keeping babies warm?

A
  • wrap or bags
  • skin to skin care
  • prewarmed incubator
  • transwarmer mattress
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12
Q

Why is there an increased risk of nutritional compromise in premature babies?

A
  • limited nutrient reserves
  • gut immaturity
  • immature metabolic pathways
  • increased nutrient demands
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13
Q

What causes early onset neonatal sepsis?

A

Mainly due to bacteria acquired before and during delivery

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14
Q

What causes late onset neonatal sepsis?

A

Acquired after delivery (nosocomial or community sources)

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15
Q

What organisms cause early onset neonatal sepsis?

A

Group B streptococcus

Gram negatives

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16
Q

Which organisms cause late onset neonatal sepsis?

A

Coagulase negative Staphylococci

Gram Negatives

Staph Aureus

17
Q

What are the risks of sepsis associated with prematurity?

A

Immature immune system

Intensive care environment

Indwelling tubes and lines

18
Q

How can risk of neonatal sepsis be managed?

A

Prevention

Hand-washing

Super vigilant and infection screening

Judicious use of antibiotics

Supportive measures

19
Q

What are the respiratory complications of prematurity?

A

Respiratory distress syndrome

Apnoea of prematurity

Bronchopulmonary dysplasia

20
Q

What is the primary pathology in hyaline membrane disease?

A

Surfactant deficiency

Structural immaturity

21
Q

What is the secondary pathology of hyaline membrane disease?

A

Alveolar damage; formation of exudate from leaky capillaries

Inflammation

Repair

22
Q

What are the clinical features of hyaline membrane disease?

A

Respiratory distress

Tachypnoea

  • grunting
    • intercostal recessions*
    • nasal flaring*
    • cyanosis*

Worsen over minutes to hours

Natural history

  • gradual worsening to nadir at 2-4 days
23
Q

What is the management of hyaline membrane disease (RDS)?

A

Maternal steroid

Surfactant

Ventilation

-invasive/non-invasive

24
Q

What is the classification and outcomes for intraventricular haemorrhage?

A

Grade 1 and 2

  • neurodevelopmental delay up to 20%
  • mortality 10%

Grade 3 & 4

  • neurodevelopmental delay up to 80%
  • Mortality 50%
25
Q

When does retinopathy of prematurity present?

A

6-8 weeks after delivery

26
Q

What are the early metabolic complications of prematurity?

A

Hypoglycaemia

Hyponatraemia

27
Q

What are the late metabolic complications of prematurity?

A

Osteopenia of prematurity