Radiation Therapy (XRT) Flashcards

1
Q

CNS tumors that are very radiosensitive includes all of the following except?
● A. Gliosarcoma
● B. Germinoma
● C. Metastatic lung cancer
● D. Lymphoma
● E. Choriocarcinoma

A

A. Gliosarcoma

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2
Q

For most metastatic spine tumors treated with conventional radiation therapy (i.e., not stereotactic radiosurgery), what is the usual fractionation?
● A. 20 Gy administered over 10 fractions
● B. 30 Gy administered over 10 fractions
● C. 60 Gy administered over 10 fractions
● D. 30 Gy administered over 5 fractions
● E. 30 Gy administered over 20 fractions

A

B. 30 Gy administered over 10 fractions

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3
Q

For acute spinal cord paralysis from lymphoma, if emergency surgery is not a consideration, what is the emergency radiation that can be given in the 1st fraction?
● A. 2 Gy
● B. 3 Gy
● C. 4 Gy
● D. 6 Gy
● E. 8 Gy

A

E. 8 Gy

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4
Q

In chronic, progressive myelopathy, what is the commonly reported radiation myelopathy type?
● A. I
● B. II
● C. III
● D. IV
● E. V

A

D. IV

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5
Q

What is the source of particle generation PET scan?
● A. Cyclotron
● B. Tungsten
● C. Cobalt 60
● D. Cobalt 62
● E. Chromium

A

A. Cyclotron

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6
Q

A patient presented with sudden-onset loss of consciousness. According to Virginia Radiosurgery AVM Scale, a 3 cm3 thalamic AVM presenting with hemorrhage will be awarded how many points?
● A. 1
● B. 2
● C. 3
● D. 4
● E. 5

A

C. 3

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7
Q

An old female patient with breast cancer presents with first-time seizures. What is the recommended dose of SRS for a 25-mm metastatic brain lesion?
● A. 10 Gy
● B. 18 Gy
● C. 24 Gy
● D. 28 Gy
● E. 30 Gy

A

B. 18 Gy

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8
Q

A patient presented with unilateral hearing loss, tinnitus, and disequilibrium. What is the recommended single dose SRS for hearing preservation and to minimize new onset or worsening of cranial nerve deficits?
● A. 12 Gy
● B. 16 Gy
● C. 18 Gy
● D. 20 Gy
● E. 25 Gy

A

A. 12 Gy

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9
Q

A young female presented with galactorrhea amenorrhea and visual field defects. What is the usual SRS dose for secretory pituitary tumors?
● A. 10 Gy
● B. 12 Gy
● C. 20 Gy
● D. 25 Gy
● E. 30 Gy

A

D. 25 Gy

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10
Q

What is the rate of clinical improvement after interstitial brachytherapy?
● A. 100%
● B. 90%
● C. 75%
● D. 50%
● E. Rare chances

A

E. Rare chances

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11
Q

What are the four Rs of radiobiology that are referred by radiation oncologists?
● A. Repair of sublethal damage
● B. Reoxygenation of tumor cells that were hypoxic before radiotherapy
● C. Repopulation of tumor cells
● D. Redistribution of cell within the cell cycle
● E. All of the above

A

E. All of the above

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12
Q

All of the following are the CNS tumors that are very radiosensitive except?
● A. Lymphoma
● B. Thyroid adenocarcinoma
● C. Germ cell tumors
● D. Metastatic small cell cancer

A

B. Thyroid adenocarcinoma

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13
Q

Radiation therapy is the main treatment modality for radiosensitive spinal metastasis. Even tumors that are considered radioresistant can respond to radiotherapy. What is the usual fractionated therapy for spinal tumors?
● A. 20 Gy administrated over 10 fractions
● B. 30 Gy administrated over 10 fractions
● C. 40 Gy administrated over 10 fractions
● D. 50 Gy administrated over 10 fractions
● E. 60 Gy administrated over 10 fractions

A

B. 30 Gy administrated over 10 fractions

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14
Q

Following are the side effects of spinal radiation except?
● A. Radiation myelopathy
● B. Due to overlap, radiation injury to GI tract
● C. Bone marrow hyperactivity
● D. Growth retardation in children
● E. Risk of development of cavernous malformation of spinal cord

A

C. Bone marrow hyperactivity

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15
Q

Small artery injury because of radiation therapy causes which phase of radiation injury?
● A. Acute phase
● B. Early delayed which starts from few weeks to 2 to 3 months following completion of radiation therapy
● C. Late delayed phase which remains from 3 months to 12 years
● D. None of the above

A

C. Late delayed phase which remains from 3 months to 12 years

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16
Q

Manifestation of radiation effects includes all of the following except?
● A. Decreased cognition
● B. Radiation necrosis
● C. Injury to optic pathways or injury to hypothalamic pituitary axis
● D. Primary hyperthyroidism
● E. May induce formation of new tumor or malignant transformation or leukoencephalopathy

A

D. Primary hyperthyroidism

17
Q

Which of the following tests can be done to differentiate radiation necrosis from recurrent tumor?
● A. MRI spectroscopy
● B. DWI
● C. Nuclear brain scan
● D. Computerized radionuclide studies including SPECT or PET
● E. All of the above

A

E. All of the above

18
Q

Which of the following are included in the treatment of radiation necrosis which may cause mass effect or otherwise toxicity?
● A. Steroids
● B. Bevacizumab
● C. Reoperation or excision
● D. Hyperbaric oxygen and anticoagulation
● E. All of the above

A

E. All of the above

19
Q

Types of radiation myelopathy include which of the following?
● A. Type 1 is mild form with mild sensory symptoms which commonly resolves within several months
● B. Type 2 is injury to anterior horn cells with lower motor neuron signs in arms or legs
● C. Type 3 is described only in experimental animals after doses larger than normal radiation. Complete cord lesion within hours occurs due to injury to blood vessels
● D. Type 4 is chronic progressive myelopathy which is commonly reported
● E. All of the above

A

E. All of the above

20
Q

Following are indications of stereotactic radiosurgery except?
● A. Vascular lesions including AVMs or cavernous malformaions
● B. Tumors which include lesions less than 3 cm which can be metastasis, vestibular schwannomas, meningiomas, pituitary adenomas, or gliomas
● C. Compressive tumors of the spinal cord, brain stem, or optic structures
● D. Functional disorders like trigeminal neuralgia or intractable chronic pain, movement disorders of psychiatric disease

A

C. Compressive tumors of the spinal cord, brain stem, or optic structures