Quiz Questions

Question 1

What is the leading cause of death in women ages 25-30 y/o?

Answer 1

Melanoma

Question 2

What blood test is used to diagnose ovarian cancer?

Answer 2

CA-125 assay

Question 3

What tube is surrounded by the prostate?

Answer 3

urethra

Question 4

What are the four places that cancers metastasize to?

Answer 4

Brain, bone, lungs, and liver

Question 5

What is the most common cancer in men ages 15-35 y/o?

Answer 5

Testicular cancer

Question 6

What is the 5 year survival rate for stage III testicular cancer?

Answer 6

74%

Question 7

In what structures to the fewest numbers of breast cancers form?

Answer 7

Lobules

Question 8

What is the most common childhood cancer?

Answer 8

ALL (acute lymphoblastic leukemia)

Question 9

The presence of what type of cell defines Hodgkins lymphoma?

Answer 9

Reed-Sternberg cells

Question 10

Which type of cancer has an Ig/Myc translocation?

Answer 10

Burkitt’s Lymphoma

Question 11

What is the most common form of adult leukemia?

Answer 11

AML (Acute Myeloid Leukemia)

Question 12

Which form of adult leukemia has the highest mortality rate?

Answer 12

AML (Acute Myeloid Leukemia)

Question 13

What drug targeted the BCR-ABL fusion in CML?

Answer 13

Gleevec

Question 14

What is the condition where you don’t have enough platelets?

Answer 14

Thrombocytopenia

Question 15

What is the most common type of ALL in adults?

Answer 15

B cell type (75%)

Question 16

What is the targeted chemotherapy that makes microbtubules too long, causing chromosome damage and cell death?

Answer 16

Taxanes

Question 17

Which cancer is associated with the gene fusion BCR-ABL1?

Answer 17

CML

Question 18

What is another name for the BCR-ABL1 gene fusion? What does the fusion result in?

Answer 18

Philadelphia chromosome; a tyrosine kinase protein that is “always on,” causing cells to divide uncontrollably.

Question 19

What is the most deadly childhood cancer?

Answer 19

Brain cancer

Question 20

What is the most deadly cancer?

Answer 20

Lung cancer

Question 21

Which cancer contains the Sonic hedgehog pathway?

Answer 21

Medulloblastoma

Question 22

Which known genetic pathway is in Medulloblastoma?

Answer 22

Sonic hedgehog pathway

Question 23

For which cancer did the NCI “gang of five” come up with combination therapy to treat?

Answer 23

Hodgkin lymphoma

Question 24

What is the lifespan for a lymphocyte?

Answer 24

200 days

Question 25

What is the life span of lymphoblasts and myeloblasts?

Answer 25

Less than a week

Question 26

What single cancer has the highest incidence?

Answer 26

Breast cancer

Question 27

What is the targeted therapy that works by making microtubules too short and thereby preventing chromosome separation?

Answer 27

Alkaloids

Question 28

What chemotherapy was discovered by Rosenberg accidentally in the 1980s?

Answer 28

Cisplatin

Question 29

From which cells do leukemias originate?

Answer 29

myeloblasts or lymphoblasts in bone marrow

Question 30

From which cells do lymphomas originate?

Answer 30

B and T cells in lymph nodes

Question 31

True or false: Risk of breast cancer increases with increasing breast density and greater breast density makes cancer harder to detect and treat.

Answer 31

True; more connective tissue and more fibroblasts allow for more cells and, therefore, more tumor

Question 32

In addition to lumpectomy, what is the key treatment for ER+ breast cancer?

Answer 32

Estrogen deprivation therapy (aromatase inhibitors or oophorectomy).

Question 33

What is the second leading cause of death in men ages 20-39?

Answer 33

Brain cancer

Question 34

What does 5-FU (Fluorouracil) inhibit?

Answer 34

TMP (this screws up the synthesis of nucleotides)

Question 35

What does methotrexate (MTX) inhibit?

Answer 35

DHFR (this screws up the synthesis of nucleotides)

Question 36

What was the treatment protocol that the Gang of Five came up with?

Answer 36

MOPP

Question 37

What does cisplatin affect?

Answer 37

DNA replication (screws it up)

Question 38

Where do small molecule inhibitors work?

Answer 38

Inside the cell

Question 39

Where do monoclonal antibodies work?

Answer 39

outside the cell (cell surface)

Question 40

Which tubulin drug works by preventing microtubule assembly (making microtubules too short)?

Answer 40

Alkaloids

Question 41

Which tubulin drug works by preventing microtubule disassembly (making microtubules too long)?

Answer 41

Taxanes

Question 42

Which cancer has the highest percentage of cancer diagnoses while the cancer is still local?

Answer 42

Skin cancer

Question 43

What characterizes the standard risk group for ALL?

Answer 43

1) 0-10 y/o 2) > 50,000 WBCs/uL 3) B-cell origin

Question 44

What characterizes the high risk group for ALL?

Answer 44

1) older than 10 y/o 2) > 50,000 WBCs/uL 3) + CSF 4) Relapse 5) Some B and T cell origin