Adult Lymphomas: Non-Hodgkin

Question 1

What percentage of Non-Hodgkin are B cell in origin?

Answer 1

85%

Question 2

What is the yearly incidence of Non-Hodgkin?

Answer 2

70,000

Question 3

How many deaths per year from Non-Hodgkin?

Answer 3

20,000

Question 4

What is the treatment for Non-Hodgkin Lymphoma?

Answer 4

Same as Hogkin: Anti-CD30 and Anti-CD20

Question 5

What are the 4 types of Non-Hodkin Lymphoma that we should know?

Answer 5

1) Anaplastic Large Cell
2) Follicular
3) Hairy Cell
4) Burkitt

Question 6

What are the risk factors for Non-Hodgkin Lymphoma?

Answer 6

Age: >66 y/o

Question 7

Which gene fusion is involved in Anaplastic Large Cell Non-Hodgkin Lymphoma?

Answer 7

NPM-ALK (works like BCR-ABL)

Question 8

Which type of Non-Hodgkin Lymphoma has a gene fusion of NPM-ALK?

Answer 8

Anaplastic Large Cell

Question 9

Which type of Non-Hodgkin Lymphoma has an IgH-Myc translocation?

Answer 9

Burkitt

Question 10

Which types of Non-Hodgkin Lymphoma have a poor prognosis?

Answer 10

Anaplastic Large Cell, Follicular, and Hairy Cell

Question 11

With what diagnostic procedure is Non-Hodgkin diagnosed?

Answer 11

Biopsy

Question 12

What is the survival rate for Non-Hodgkin?

Answer 12

75% (5 year) or 30% (10 year)