Adult Leukemias: ALL

Question 1

What percentage of ALL cases occur in adults?

Answer 1

40%

Question 2

What type of leukocute cell do most (75%) of adult leukemias come from?

Answer 2

B-cells

Question 3

What is the survival rate of adult ALL?

Answer 3

80-90%

Question 4

Are most ALL deaths in adults or children?

Answer 4

adults (80%)

Question 5

What is the yearly incidence of adult ALL?

Answer 5

6000

Question 6

What is the yearly death rate of adult ALL?

Answer 6

1500

Question 7

What is the #1 risk factor for adult ALL?

Answer 7

Exposure to radiation or chemicals

Question 8

What factors does the prognosis of ALL depend on?

Answer 8

1) Age: young better than older
2) Cell type: T is better than B
3) One bad gene translocation: T(4:11)

Question 9

What gene translocation is associated with a bad ALL prognosis?

Answer 9

t(4:11)

Question 10

What is the treatment for ALL

Answer 10

1) 2 years of chemo
2) radiation
3) Stem cell transplant

Question 11

What condition can result from ALL treatment?

Answer 11

Treatment-induced AML (then need full-body radiation)

Question 12

Stem cell transplant from another person

Answer 12

Allogenic

Question 13

Stem cell transplant using one’s own stem cells

Answer 13

autologous