Adult Leukemias: CML Flashcards
1
Q
What is the treatment for CML?
A
Gleevec (targets BCR-ABL fusion)
2
Q
What is the BCR-ABL fusion that forms an oncogene called?
A
Philadelphia chromosome
3
Q
True or false: BCR-ABL fusion is a tumor suppressor.
A
False; it is an oncogene
4
Q
Before what drug, CML was very deadly.
A
Gleevec
5
Q
What is the yearly incidence of CML?
A
6500
6
Q
What is the number of deaths per year from CML?
A
1100
7
Q
What is the survival rate of CML since Gleevec?
A
90%
8
Q
How does Gleevec work?
A
Binds to the pocket on ABL, preventing ABL from being phosphorylated and jamming up the BCR-ABL oncogene.
9
Q
What causes CML to commonly relapse?
A
Mutation of the binding pocket on BCR-ABL, preventing Gleevec from being effective.
10
Q
What is the key symptom of CML?
A
Fullness in the belly (enlarged spleen).
