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Z - pharmacology > quiz 6 NSAID > Flashcards

quiz 6 NSAID Flashcards

1
Q

PGE and PGI2 decrease what?

A

volume and acidity of gastric secretions

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2
Q

PGE and PGI2 increase what? (3)

A
  • sodium bicarbonate secretion in the GI tract
  • gastric and intestinal mucus production
  • turnover and repair of GI epithelial cells
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3
Q

what does sodium bicarbonate do in the GI tract?

A

counters acidity

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4
Q

adverse effects of NSAIDs in the GI tract are due to what?

A

decreased protective prostaglandin production which protect from ulcer formation (PGE, PGI2)

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5
Q

this animal is more resistant to NSAIDs

A

horse

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6
Q

unlike glucocorticoids, NSAIDs DON’T cause what? (4)

A
  • immunosuppression
  • pregnancy problems
  • changes in CBC
  • glucose regulation
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7
Q

NSAIDs can cause this in the kidney

- why?

A

renal tissue necrosis

- decreased protective prostaglandin production (PGE2)

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8
Q

what does PGE2 do?

A

causes dilate the arteries to help increase blood flow to the kidney

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9
Q

how do NSAIDs affect blood flow?

A

they decrease the body’s ability to compensate for decreased blood flow

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10
Q

these 2 NSAIDs are mostly used in horses

A
  • Phenylbutazone

- Flunixin Meglumine

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11
Q

this inhibits cyclooxygenase

A

phenylbutazone

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12
Q

this can cause

  • GI ulcers
  • renal necrosis
  • retention of water and sodium
  • bone marrow suppression
A

phenylbutazone

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13
Q

this has potent analgesic properties

A

Flunixin Meglumine

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14
Q

this is used to relieve inflammation and severe pain in horses

A

Flunixin Meglumine

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15
Q

this reduces fever in small animals

A

Flunixin Meglumine

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16
Q

Flunixin Meglumine cause GI ulcers after how long

A

about ~3-4 days of use in dogs

17
Q

of Ibuprofen, Ketoprofen, and Naproxen, which is sometimes used in animals?

A

Naproxen (Equiproxen)

18
Q

Ibuprofen, Ketoprofen, and Naproxen are derived from

A

propionic acid and have similar qualities

19
Q

Ibuprofen, Ketoprofen, and Naproxen inhibit

A

cyclooxygenase and lipooxygenase

20
Q

active ingredient in advil?

A

ibuprofen

21
Q

Ibuprofen, Ketoprofen, and Naproxen can cause GI ulcers after

A

? days of use

22
Q

this NSAID is highly protein bound

A

Phenylbutazone

Z - pharmacology (44 decks)

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