QUIZ 3 Salivary Gland Secretion

Question 1

label this gland

Answer 1

Question 2

serous deminlunes are only seen in the ___ gland

Answer 2

submandibular

Question 3

where is the nucleus in serous cells?

Answer 3

centered

Question 4

where is the nucleus in mucus cells?

Answer 4

pushed back towards basolateral side

Question 5

describe the components needed to produce saliva

Answer 5

know this well

Question 6

describe the two stage saliva secretion model

Answer 6

Question 7

what allows saliva to have unidirectional secretion in acinal cells?

Answer 7

tight junctions

Question 8

what are the important transporters in stage 1 of saliva secretion?

Answer 8

Question 9

if you block Ik1 OR Maxi-K potassium channels what happens? what about if you block both?

Answer 9

• block one or the other - no change in saliva secretion
• block both - saliva secretion reduced by about 30%

Question 10

describe stage 2 NaCl reabsorption and potassium secretion in saliva secretion

Answer 10

know the Cftr chloride channel

Question 11

what are the 4 protein secretion pathways?

Answer 11

• constitutive pathway
• constitutive-like pathway
• major regulated pathway
• minor regulated pathway

Question 12

describe the constitutive pathway of protein secretion

Answer 12

transport cell membranes protein in vesicles to cell membrane and does not require neurotransmitters

Question 13

describe the constitutive-like pathway of protein secretion

Answer 13

transport of secretory proteins in vesicles that bud from golig minimal agonist concentration

Question 14

describe the major regulated pathways of protein secretion

Answer 14

rapid release of granules that fusion to the luminal cell surface, high doses of neurotransmitter

Question 15

describe the minor regulated pathways of protein secretion

Answer 15

slow release of granules of vesicles that release from maturing secretory granules, low doses of neurotransmitter (human common salivary protein I)

Question 16

saliva is 99.5% ___

Answer 16

water

Question 17

what are the 11 functions of saliva?

Answer 17

• fluid/lubricant
• ion reservoir
• buffer
• cleansing
• antimicrobial actions
• agglutination
• pellicle formation
• digestion
• taste
• excretion
• water balance

Question 18

what is sjogren’s syndrome?

Answer 18

an autoimmune disease that generally affects women of postmenopausal age

lymphocytes infiltrate salivary glands and affect function

Question 19

describe side effects of radiation treatment on salivary glands

Answer 19

lots of collagen present, and destruction of the glands

Question 20

protein secretion occurs as a complete fusion of ___ at the ___ membrane

Answer 20

• secretory granules
• apical

Question 21

in saliva secretion, basolateral transporters concentrate ___ above its electrochemical gradient

Answer 21

chloride

Question 22

salivary gland function is impaired in which 4 major conditions?

Answer 22

• sjogren’s syndrome
• post-irradiation
• developmental defects
• drug-induced xerostomia