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MedBiochem > quiz 2.4 eico and LPPs > Flashcards

quiz 2.4 eico and LPPs Flashcards

1
Q

eicosa means

A

20 bcoz eicosanoids are synthesized from 20-carbon PUFAs

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2
Q

what kind of hormone ang eico

A

local

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3
Q

san galing prostaglandins

A

prostate pero iba na din

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4
Q

san galing thromboxane

A

platelets

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5
Q

san galing leukotrienes

A

leukocytes

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6
Q

biologically significant eicosanoids are from

A

arachidonic acid from cellular stores

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7
Q

minir eicosanoids are from

A

a-linolenic

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8
Q

3 enzyme system of eicosanoid metab

A

lipooxy
cycloxy
cytochrome

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9
Q

ano produces sa cyclooxy pathway

A

prostagla

thrombo

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10
Q

action ng steroidal anti-inflamm drugs

A

stop the patheay at membrane phospholipid

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11
Q

drugs that inhibit cyclooxygenase path

A

aspirin
NSAIDS
indomethacin
phenylbutazone

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12
Q

prostaglandin structurally is a 20-carbon atom thas has

A

internal saturated 5-carbon ring (C8-12/head)

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13
Q

ano tinatanggal sa eico para madegrade

A

OH @ C15

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14
Q

ano nsa eico cis or trans

A

trans

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15
Q

where does substituents attach in the eico

A

C9 and C11

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16
Q

rwhere is PGO found

A

endothelial cells

17
Q

unique stru ture in thromboxane

A

oxane ring

18
Q

function of TXA2

A

platlet aggre

19
Q

explain mechanism of aspirin

A

inhibits thromboxane formation in olatelets

20
Q

what is degraded from Txa2

A

TXB2

21
Q

prosta H2 >(___)> TXA2

A

TXA2 synthase

22
Q

essential for TX formation and integirty of gastrointestinal epithelium

A

COX1

23
Q

stimulated by growth factors, cutokines and endotoxins

inducible

A

COX2 or PGS2

24
Q

2 isoforms of PGH2 suynthase

A

COX1 and COX2

25
Q

COX 1 and 2 are

A

isoforms of PGH2 synthase

26
Q

synth of leukotrienes begin with

A

formation of HPETE

27
Q

peoduct ng cytchrome pathway

A

epoxides

28
Q

prod ution site of PGD2

A

mast cells

MedBiochem (16 decks)

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