quiz 2.4 eico and LPPs Flashcards
eicosa means
20 bcoz eicosanoids are synthesized from 20-carbon PUFAs
what kind of hormone ang eico
local
san galing prostaglandins
prostate pero iba na din
san galing thromboxane
platelets
san galing leukotrienes
leukocytes
biologically significant eicosanoids are from
arachidonic acid from cellular stores
minir eicosanoids are from
a-linolenic
3 enzyme system of eicosanoid metab
lipooxy
cycloxy
cytochrome
ano produces sa cyclooxy pathway
prostagla
thrombo
action ng steroidal anti-inflamm drugs
stop the patheay at membrane phospholipid
drugs that inhibit cyclooxygenase path
aspirin
NSAIDS
indomethacin
phenylbutazone
prostaglandin structurally is a 20-carbon atom thas has
internal saturated 5-carbon ring (C8-12/head)
ano tinatanggal sa eico para madegrade
OH @ C15
ano nsa eico cis or trans
trans
where does substituents attach in the eico
C9 and C11
rwhere is PGO found
endothelial cells
unique stru ture in thromboxane
oxane ring
function of TXA2
platlet aggre
explain mechanism of aspirin
inhibits thromboxane formation in olatelets
what is degraded from Txa2
TXB2
prosta H2 >(___)> TXA2
TXA2 synthase
essential for TX formation and integirty of gastrointestinal epithelium
COX1
stimulated by growth factors, cutokines and endotoxins
inducible
COX2 or PGS2
2 isoforms of PGH2 suynthase
COX1 and COX2
COX 1 and 2 are
isoforms of PGH2 synthase
synth of leukotrienes begin with
formation of HPETE
peoduct ng cytchrome pathway
epoxides
prod ution site of PGD2
mast cells
