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HBHD > Q2 Antidepressants Module > Flashcards

Q2 Antidepressants Module Flashcards

1
Q

depression is a result of which neurotransmitters

A
  • low: serotonin, NE, and dopamine
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2
Q

MOA of MAOIs

A
  • irreversible inhibition of MAO-A and MAO-B

- slows down metabolism of neurotransmitters

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3
Q

what else does monoamine oxidase break down

what happens if it can’t break it down

A
  • tyramine
  • excess tyramine displaces serotonin, NE, and DA.
  • excess NE and DA causes vasoconstriction leading ot hypertensive emergency
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4
Q

what does MAO-A break down

A
  • tyramine
  • serotonin
  • NE
  • dopamine
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5
Q

what does MAO-B break down

A
  • dopamin
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6
Q

examples of MAOis

A
  • Selegiline
  • Tranycypromine
  • Phenelzine

MAO TPS

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7
Q

importance of Selegiline at lose doses

how do you give it

A
  • just MAO-B inhibitor
  • bypasses GI tract
  • it’s a patch
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8
Q

negative effect of MAOi combined with SSRI

A
  • serotonin syndrome
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9
Q

symptoms of serotonin syndrome

A
  • hyperthermia
  • autonomic instability
  • delirium
  • muscle rigidity
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10
Q

when switching from an SSRI to an MAOi, how long must you wait

what about when switching from Fluoxetine specifically

what is the big risk

A
  • 2 weeks
  • 5 weeks
  • serotonin syndrome
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11
Q

what do we use MAOIs to treat

A
  • atypical depression
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12
Q

what class of drug is Clomipramine

what do we use it to treat

A
  • TCA

- OCD

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13
Q

what do we use to treat OCD

A
  • Clomipramine
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14
Q

what are examples of tertiary TCAs

A
  • amitriptylline
  • imipramine
  • clomipramine

IM AM CLO

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15
Q

what are examples of secondary TCAs

A
  • nortriptylline
  • protriptylline
  • desipramine

DES NO PRO (Dis no problem)

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16
Q

adverse effects of TCAs

A
  • cardiotoxicity
17
Q

we use low dose TCAs for what

A
  • neuropathic pain
  • migraine prophy
  • insomnia
18
Q

when SSRIs are used for MDD, it can take how long to see a response

what symptoms improve first

what symptoms improve last

A
  • 3-4 weeks
  • energy level
  • anhedonia, mood, cognitive symptoms
19
Q

warning with SSRIs

A
  • may cause suicidal thoughts and behaviors in children and young adults
20
Q

shorter half-life of SSRIs can cause

A
  • withdrawal syndrome
21
Q

non transient adverse effects of SSRIs

A
  • SIADH

- sexual adverse effects

22
Q

SIADH adverse effect of SSRIs is most common in what population

A
  • elderly
23
Q

what are some examples of SSRIs

half lives

what is the benefit/bad part with half lives

A
  • paroxetine (less than 24 hours)
  • citalopram (24 hours)
  • escitalopram (24 hours)
  • sertraline (24 hours)
  • fluoxetine (a week)
  • short half lives can result in withdrawal syndrome
24
Q

transient effects of SSRIs

A
  • GI upset

- headache

25
Q

paroxetine and fluoxetine inhibit

watch out for _____ when combined with antipsychotics

A
  • 2D6

- extra pyramidal symptoms

26
Q

symptoms of SSRI and SNRI withdraw syndrome

A
  • flu-like symptoms
  • light headedness
  • uneasiness
  • sensory disturbance
  • headache
  • FLUSH
27
Q

what are the examples of SNRIs

A
  • venlafaxine
  • desvenlafaxine
  • duloxetine
  • milnacipram
  • levomilnacpram
  • VDM
28
Q

side effect of venlafaxine

A
  • dose related HTN
29
Q

side effect of duloxetine

A
  • LFT increase
30
Q

effects of milnacipram and levomilnacpram

A
  • norepinephrine effects
31
Q

SNRIs are used for treatment of

A
  • pain
32
Q

Trazadone used to treat

side effects

A
  • insomnia

- orthostatic hypotension

33
Q

Nefazodone side effects

A
  • hepatotoxicity
34
Q

Buproprion used to treat

avoid in

side effects

A
  • Antidepressant that
    doesn’t cause sexual dysfunction!!
  • smoking cession
  • ADHD
  • Anxiety
  • Bipolar
  • epilepsy
  • seizure disoders
  • constipation
  • insomnia
35
Q

side effects of Mirtazapine

A
  • weight gain

- sedation

36
Q

adverse effects of lithium

A
  • polydipsia and polyuria
  • nephrogenic DI
  • Ebstein’s anomaly if in first trimester
37
Q

what organs can lithium interact with

what side effects

A
  • thyroid - hypothyroidism/goiter

- kidney

38
Q

what drugs do you avoid taking with lithium due to kidney effects

A
  • thiazide diuretics
  • ACE inhibitors and ARBs
  • NSAIDs

HBHD (23 decks)

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