Q1 Stimulants Module Flashcards
1
Q
the modern indication of stimulants is for what condition
A
- ADHD
2
Q
labeled FDA indication for stimulants
what side effects do they capitalize on
A
- ADHD
- narcolepsy - wakefulness
- binge eating disorder - appetite suppression
3
Q
stimulants are what schedule of medication
A
- class 2
4
Q
why do we not use stimulants to treat psychosis
A
- stimulants cause increased availability of dopamine
- increased dopamine causes psychosis
5
Q
MOA of caffeine
A
- drip of NE and dopamine into synaptic space of prefrontal cortex
6
Q
MOA of amphetamines
A
- dose dependent increase of NE in prefrontal cortex
- increase of dopamine in striatum
7
Q
MOA of crystal methamphetamine or cocaine
A
- flood synaptic space with dopamine and NE
- then deplete NE and dopamine causing crash
8
Q
MOA of methylphenidates
A
- inhibits NE transporter and dopamine transporters
- increase NE and dopamine
9
Q
common concerns of psychostimulants
A
- weight/growth/height deficits
- headache/GI upset
- increase tics
- CV events
10
Q
psychostimulants cause release of what hormones
A
- corticotropin-releasing factor
- corticotropin
- cortisol
11
Q
what is the response rate of amphetamines and methylphenidate
A
- 80-90%
12
Q
MOA of Clonidine
- selective for which receptors
- half life
A
- pre/post synaptic alpha 2 agonist
- nonselective at alpha 2A, 2B, and 2C
- longer half life
13
Q
MOA of guanfacine
- selective for which receptors
- half life
A
- post synaptic alpha 2 agonist
- selective for alpha 2A receptor
- shorter half life
14
Q
MOA of atomoxetine
- onset of effects
A
- NE reuptake inhibitor
- 2-3 weeks
15
Q
side effects of clonidine
A
- high rate of rebound hypertension
- hypotension
- headache
- dry mouth
- fatigue
