Pulmonary Hypertension Flashcards
What is the diagnostic definition of Pulmonary Hypertension?
Resting mean Pulmonary Artery Pressure at or above 25mmHg (normal 18-25) - gold-standard measure : right heart catheterisation.
Pathophysiology of Pulmonary Hypertension.
Increased resistance and pressure of blood in the pulmonary arteries.
Aetiology of Pulmonary Hypertension (5).
- Primary Pulmonary Hypertension or Connective Tissue Disease (e.g. SLE).
- Left Heart Failure (e.g. MI, HTN).
- Chronic Lung Disease (e.g. COPD).
- Pulmonary Vascular Disease (e.g. PE).
- Miscellaneous e.g. Haematological Disorders, Glycogen Storage Disease, Sarcoidosis.
Clinical Presentation of Pulmonary Hypertension (3).
- Shortness of Breath.
- Syncope, Tachycardia.
- HF : Raised JVP, Hepatomegaly, Peripheral Oedema.
ECG Changes in Pulmonary Hypertension (3).
Right-Sided Strain :
- RV Hypertrophy - Larger R waves on Right-Sided Leads (V1-V3) and S waves on Left-Sided Leads (V4-V6).
- Right Axis Deviation.
- RBBB.
- P-Pulmonale.
CXR Changes in Pulmonary Hypertension (2).
- Dilated Pulmonary Arteries.
2. Right Ventricular Hypertrophy.
Other Investigations in Pulmonary Hypertension.
- Echo - Estimate Pulmonary Artery Pressure.
- Raised NT-pro-BNP : RV Failure.
- Right Heart Catheterisation (Gold-Standard).
Management of Primary Pulmonary Hypertension (3).
- IV Prostanoids e.g. Epoprostenol.
- Endothelin Receptor Antagonists e.g. Macitentan, Bosnian.
- PDE-5 Inhibitors e.g. Sildenafil.
Management of Secondary Pulmonary Hypertension.
Treatment of underlying cause e.g. PE, SLE.
Prognosis of Pulmonary Hypertension.
30-40% 5 Year Survival (60-70% with specific treatment).