Asthma - Pharmacology

Question 1

Mechanism of Action of SABA.

Answer 1

Short-Acting B2 Agonist - to relax smooth muscle of airways.

Question 2

Examples of SABA.

Answer 2

1. Salbutamol.

2. Terbutaline.

Question 3

Mechanism of Action of ICS.

Answer 3

Inhaled Corticosteroid - reduce inflammation and reactivity of airways.

Question 4

Adverse Effects of ICS.

Answer 4

1. Oral Candidiasis.
2. Stunted Growth in Children.
3. Hoarse Voice.
4. Osteoporosis and Adrenal Suppression at High Doses.

Question 5

Mechanism. of Action of LABA.

Answer 5

Long-Acting B2 Agonist.

Question 6

Caution of LABA.

Answer 6

Should only be taken with a steroid (risk of death).

Question 7

Adverse Effects of LABA.

Answer 7

Muscle Cramps.

Question 8

Examples of LABA.

Answer 8

1. Salmeterol.

2. Formoterol (Fast-Acting).

Question 9

Mechanism of Action of LRA.

Answer 9

Oral Leukotriene Receptor Antagonist.

Question 10

Examples of LRA.

Answer 10

Montelukast.

Question 11

Mechanism of Action and Indication of MART.

Answer 11

Combined low-dose ICS and fast-acting LABA treatment in a single inhaler.

Question 12

Examples of LAMA.

Answer 12

Tiotropium.

Question 13

Mechanism of Action of Theophylline.

Answer 13

Relaxes bronchial smooth muscle and reduces inflammation.

Question 14

Caution of Theophylline.

Answer 14

Narrow therapeutic window - toxic in excess so plasma theophylline levels are tested 5 days after starting and 3 days after each dose change.