Puberty Flashcards

1
Q

What is puberty?

A

A stage of human development when sexual maturation and growth are completed and result in ability to reproduce

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2
Q

Which gender starts puberty first?

A

Females

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3
Q

What is the critical weight for female puberty?

A

47 kg

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4
Q

What is the usual age range for female puberty?

A

9-13

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5
Q

What is the order of onset of female puberty?

A

Breast bud formation
Pubic hair growth
Growth spurt
Menarche

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6
Q

What is thelarche?

A

Onset of secondary breast development

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7
Q

What is menarche?

A

Starting of period

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8
Q

What staging system is commonly used in puberty?

A

Tanner system

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9
Q

What is the tanner system for breast development?

A

Stage 1 = prepubertal
Stage 2 = breast bud stage - elevation of breasts and papilla
Stage 3 = further enlargement of breast and areola
Stage 4 = areola and papilla form secondary mound
Stage 5 = mature stage - projection of papilla only

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10
Q

What is the tanner system for pubic hair?

A

Stage 1 = prepubertal
Stage 2 = sparse growing of long hair
Stage 3 = darker, coarser and more curled hair - begins to extend laterally
Stage 4 = hair covering smaller area than adult
Stage 5 = adult in type and quantity

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11
Q

What is the age range for male puberty?

A

10-14

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12
Q

What is the order of onset of male puberty?

A

Testicular volume increases
Genital size growth
Pubic hair
Growth spurt

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13
Q

What is the tanner system for genital size?

A

Stage 1 = prepubertal
Stage 2 = enlargement of scrotum + testes
Stage 3 = enlargement of penis
Stage 4 = growth of penis breadth, scrotum skin darker
Stage 5 = adult genitalia

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14
Q

What is the tanner system for growth in females?

A
Stage 1 = 5-6cm per year
Stage 2 = 7-8cm per year
Stage 3 = 8cm per year
Stage 4 = 7cm per year
Stage 5 = no growth after 16 years
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15
Q

What is the tanner system for growth in males?

A
Stage 1 = 5-6cm per year
Stage 2 = 5-6cm per year
Stage 3 = 7-8cm per year
Stage 4 = 10cm per year
Stage 5 = no growth after 17 years
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16
Q

Why do males have a longer growth spurt?

A

Growth spurt is ended by fusion of epiphyseal growth plates

Oestrogen causes fusion earlier in females

17
Q

What system initiates puberty?

18
Q

Describe the HPG axis

A

Hypothalamus produces GnRH

Anterior pituitary produces LH + FSH

Gonads produce androgens + oestrogen

19
Q

What is GnRH?

A

Gonadotropin releasing hormone

20
Q

How is GnRH released?

A

Released in pulses from hypothalamus

21
Q

What does LH act on in males?

A

Leydig cells

22
Q

What does LH stimulate Leydig cells to secrete?

A

Testosterone

23
Q

What does FSH act on in males?

A

Sertoli cells

24
Q

What does FSH stimulate Sertoli cells to secrete?

25
What is the role of inhibin?
Produce negative feedback at pituitary
26
What does LH act on in females?
Theca cells
27
What does LH stimulate theca cells to secrete?
Androgens | Progestins
28
What is the role of androgens?
Act on granulosa cells
29
What is the role of progestins?
Increases inhibitory effect of moderate oestrogen Prevents positive feedback of high oestrogen
30
What does FSH act on in females?
Granulosa cells
31
What does FSH stimulate granulosa cells to secrete?
Inhibin | Oestrogen
32
What is the role of oestrogen?
Moderate oestrogen = negative feedback on hypothalamus High oestrogen = Positive feedback on hypothalamus = LH surge
33
What is leptin?
Adipocyte-derived protein hormone
34
What is the role of leptin?
Regulates neuroendocrine function | - accelerate onset of reproductive function