Psychology 7a - Psychobiology Flashcards

1
Q

What is stress?

A
  • A stimulus
  • Events that place strong demands on us are stressors
  • Eg. exam period
  • A response
  • Physiological response to stress (fight-flight)
  • Presence of negative emotions, difficulty concentrating
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2
Q

What are the effects of stress?

A
  • SNS activation
  • HPA axis activation (cortisol production)
  • Adaptive response
  • Exhaustion of adrenal glands in chronic stress
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3
Q

Describe the transactional model of stress

A
  • Stress occurs when there is imbalance between percieved demands and the resources we have to deal with these demands
  • Primary appraisal to determine if a threat is present, secondary appraisal to determine how to cope with the threat
  • May be perception of an inability to cope or ability to cope
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4
Q

Describe cognitive appraisal using exams as an example

A
  • When considering an exam you will evaluate how hard it will be and how much it counts (primary appraisal) and how your current knowledge equips you to pass (secondary appraisal)‏
  • You will also take into account potential consequences of failing with regards to their likelihood and seriousness
  • Finally, the psychological meaning of the consequences may be related to your beliefs about yourself or the world, e.g. “I am a total failure if I don’t do well in all my exams”
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5
Q

Describe Yerkes-Dodsan Law

A
  • It is good to have a small amount of stress arousal, with small amount of arousal there is optimal level of performance
  • Performance impaired with strong anxiety
  • Low arousal weak performance as there is low interest
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6
Q

Describe behavioural change pathways from stress to disease, using examples

A
  • Stress can cause behavioural changes that increase risk of disease
  • Eg. increased smoking and alcohol just before an exam, decreased exercise.
  • Increased smoking in those with low levels of perceived support and increased alcohol use compared with those with high levels of perceived support
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7
Q

Describe physiological stress pathways from stress to disease, using examples

A
  • Stress may cause physiological changes that increase risk of disease
  • Eg. significantly increased incidence of heart attack at the time of the world cup (day of match to 2 days after)
  • Eg. anxiety is associated with 52% increased risk of heart disease (independent of traditional risk factors and depression)
  • Eg. heightened cortisol reactivity in response to mental stressors associated with greater extent of coronary artery calcification
  • Eg. mucosal wound healing time increases just before a major exam by an average of 40% longer (possibly due to declined interleukin 1)
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8
Q

How does personality relate to illness?

A
  • Western collaborative group study found that type A behaviour pattern increased CHD risk in healthy males by double when controlling other risk factors
  • Type A behaviour pattern alone, when compared to type B increased risk by 31%
  • Role of hostility may be a key type A behavioural factor in CHD
  • Due to poor health behaviours, increased physiological response to stresses, endothelial dysfunction and atherosclerosis
  • Possible link between type D behaviour (social inhibition and negative effect) has relationship with CHD due to underreporting of symptoms
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9
Q

Give examples of the type A behaviour pattern

A
  • Time urgency
  • Free floating hostility
  • Hyper-aggressiveness
  • Focus on accomplishment
  • Competitive and goal driven
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10
Q

What is depression a risk factor for?

A
  • Development of CHD
  • Prognosis of CHD (higher risk of mortality in the first two years)
  • Possible due to physiological changes (platelet activity) or behavioural changes (lack of physical activity)
  • Depression is a more significant risk factor of mortality than previous MI/ severity of MI
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11
Q

How is stress coped with?

A
  • Problem focused (planning, active coping and problem solving, assertive confrontation)
  • Emotion focused (acceptance or denial, repression, positive reinterpretation)
  • Seeking social support (help and guidance, emotional support)
  • Approach vs avoidance techniques
  • Swearing as pain relief (swearing decreased perceived pain in a study using cold pressor, as well as increasing time in cold, possibly via fight or flight activation)
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12
Q

Describe approach and avoidance techniques of dealing with stress

A
  • Approach is activity that is oriented toward a threat (e.g. problem-solving, planning a response). People may want to discuss illness and treatment in detail
  • Avoidance is activity that is oriented away from a threat (e.g., denial, distraction). People may find it difficult to engage in discussions around illness and treatment
  • Utility of coping style may depend on the situation
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13
Q

How does social support affect stress?

A
  • People with higher social support had a 50% greater likelihood of longer survival compared to those with lower support
  • Controlled for depression
  • Breast cancer survival increased with social support, as did quality of life
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14
Q

How does branding affect pain relief?

A
  • Branded analgesic had significantly more effect than non-branded analgesic
  • Placebo in branded box had significantly more effect than placebo in a non-branded box
  • Due to placebo effect
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15
Q

What is the placebo effect?

A

The phenomenon in which a placebo - an inactive substance like sugar, distilled water, or saline solution - can sometimes improve a patient’s condition simply because the person has the expectation that it will be helpful.

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16
Q

What is the nocebo effect?

A
  • A negative effect that occurs after receiving treatment (therapy, medication), even when the treatment is inert/sham
  • Warnings about the possible side effects of a medicine makes it much more likely that the patient will report experiencing those effects
  • One out of 20 placebo treated patients discontinued treatment due to ‘side effects
17
Q

How could placebo be used as a treatment?

A
  • Chronic medication is an increasing issue
  • eg. doubled opioid precription in the UK
  • Placebos could be use to reduce medication use and associated side effects
  • Topical steroid cream use in psoriasis. After 6 weeks, split into half dose, full dose and half placebo mixed in with half dose (visually same amount). Half dose (visually smaller amount) had increased relapse rate, half placebo had similar effect to full dose
18
Q

List psychological mechanisms underlying the placebo effect

A
  • Framing (perception of effect influences the reported effect)
  • Social learning (observing others getting better)
  • Experiential learning (learning through experience of positive results from active medication can influence expectations and therefore response from inactive mediaction)
  • Classical conditioning (placebo looks like the active treatment/ administered in the same way, so the placebo is an associated conditioned stimuli which can cause the conditioned response of therapeutic effect)
19
Q

What are the clinical implications of placebo effect?

A
  • Increased effect of interventions by how they are presented (in form and in manner using framing)
  • Could be particularly helpful in conditions with psychological components
  • Placebos free of negative side effects (however there is nocebo efect)
  • 80% HCPs have used placebos
20
Q

How could placebo be used without deception?

A
  • Study looked at patients with IBS and gave them open placebo (told them it was made of an inert substance)
  • Open placebo was more effective in improving quality of life than no treatment, as well as symptom improvement
21
Q

Describe Selye general adaptation syndrome

A
  • Stage 1: alarm reaction (shift to sympathetic sominance causes increased arousal)
  • Stage 2: resistance (endocrine system releases stress hormones to maintain increased arousal)
  • Stage 3: exhaustion (the adrenal glands lose their ability to function normally)