Musculoskeletal 10 - Arthritis 11 & Fractures Flashcards

1
Q

What is the Heuter-Volkmann principal?

A
  • Bones respond to the compression and tension you put on them
  • Increased compression (pressing) decreases longitudinal growth, increased tension (pulling) increases longitudinal growth
  • Therefore, affects growth of the bone
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2
Q

Define varus and valgus

A
  • Bow legged (away from the midline) is varus
  • Knees pointing towards the midline is valgus (knock-knee)
  • Results in uneven distribution of weight on the knee
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3
Q

How do varus and valgus deformities affect osteoarthritis risk?

A
  • Varus deformities increase pressure on the medial half of the knee joint
  • Valgus deformities increase pressure on the lateral half of the knee joint
  • Therefore, this erodes the joint and alters the gap between the bones
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4
Q

What is an osteotomy?

A
  • Cut the tibia to change the shape of the leg

- Used to attempt to delay osteoarthritis

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5
Q

What is Wolffs law?

A
  • Bone responds to the stresses put on it
  • If a bone is used more (increased load), it remodels to become stronger and resists loading
  • If a bone is used less (decreased load), it will become less dense and weaker
  • Going to space decreases density, sport increases density
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6
Q

What is developmental dysplasia of the hip?

A
  • Disorder affecting babies
  • In utero, ball of the hip is not aligned in the socket, and therefore the hip socket does not become rounded in response (due to Wolffs law)
  • More likely in females, babies that are breech, and the right hip (as this hip is pushed towards the spine)
  • Affected by in-utero behaviour (baby kicking)
  • Increased risk of osteoarthritis even if the joint is loose and not dislocated
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7
Q

Describe cam and pincer hips

A
  • Cam impingement (in those who do a lot of exercise) causes the femoral neck to become thicker due to Wolffs law. Deep flexion therefore knocks into the labrum.
  • Pincer impingement causes formation of a deep socket, In deep flexion, the socket is hit by the femoral neck despite it being normal, and the femoral head on the other side.
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8
Q

List main groups who are affected by osteoarthritis

A
  • Elderly (use over time)
  • Injury (torn labrum)
  • Shape of the bone in young people (eg. knees and hip)
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9
Q

What is the most effective way of treating arthritis?

A
  • Exercise (strengthens muscles to reduce the strain on joints)
  • Joint replacement (however, only last 20 years as bone underneath breaks down due to lack of pressure ie. Wolffs law, and once replaced less effective)
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10
Q

Describe structure of a synovial joint

A
  • Two bones articulating together with cartilage (fibrocartilage or hyaline cartilage)
  • Synovial fluid between the bones
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11
Q

Describe the structure of articular cartilage

A
  • Superficial layer (collagen fibres completely horizontal, as this is the gliding zone)
  • Middle transitional zone (oblique fibres, must resist compression and gliding)
  • Deep zone (horizontally directed cartilage, main function is resistance to compression)
  • Tidemark prevents infections entering the joint (however, the lack of blood supply does not allow repair)
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12
Q

Describe the arcade model of benninghoff

A

Collagen fibril changes from horizontal in the superficial layer, to oblique in the middle layer to vertical in the deep layer

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13
Q

How do torn ACLs occur and what is the consequence?

A
  • Internal rotation upon a straight leg
  • Affects the alignment , the femur is further back on the tibia. Results in abnormal loading and therefore possible risk of arthritis, and meniscal tears
  • ACL important for pivoting, and protecting the cartilage to ensure it is loading in the correct position
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14
Q

Compare Z score and T score from DEXA scans

A
  • Z score is a comparison of a persons bone density with that of an average person of the same age and sex
  • T score is a comparison of a persons bone density with a healthy 30 year old of the same sex
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15
Q

What is the risk of bisphosphonates?

A
  • Abnormal fractures as bone is “dead”, and abnormally formed
  • Eg. fracture of the body of the femur when just walking
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16
Q

How does denosumab work?

A
  • Blocks RANKL receptors (monoclonal antibody)
  • Therefore, prevents osteoclast upregulation
  • Short half life
17
Q

When is peak bone mass formation?

A
  • Pre-pubertal stage is where bone mass increases the most, hence why calcium is so important
  • Those with osteoporosis also told to increase calcium and vitamin D intake
18
Q

How do fractures heal?

A
  • Surgically (directly putting two bones together with a mental plate to compress bone ends against one another)
  • Healing by callus
19
Q

List types of fractures

A
  • Spiral fracture due to twisting
  • Oblique fracture due to compression (diagonal)
  • Butterfly fragment (direct hit, a piece of bone tends to fall off)
  • Transverse fracture due to tension (pulling bone apart)
  • Greenstick fractures (in children, as they have a thick periosteum bones can bend)
20
Q

Compare fracture and break

A

Both are the same

21
Q

Describe the location of the ACL

A

Lateral femoral condyle to the anterior intercondylar eminence of tibia

22
Q

Describe location of the PCL

A

Anterolateral aspect of medial femoral condyle to the posterolateral aspect of tibia

23
Q

Describe the process of healing by callus

A
  • Movement is preserved if someone is in a plaster or a rod is inserted
  • Stage 1 (up to 1 week): initially formation of a hematoma. Contains macrophages, leukocytes. Granulation tissue forms, and progenitor cells invade
  • Stage 2 (1-4 weeks): Soft callus (collagen) formation. Chondrogasts and fibroblasts form collagen and fibrous tissue. Proteoglycans are produced, and chondrocytes release calcium into the ECM to allow mineralisation.
  • Stage 3 (1-4 months): soft callus is invaded by blood vessels, forms a hard callus (woven bone)
  • Stage 4 (up to several years): remodelling from woven to lamellar bone, shape is relative stresses due to Wolffs law
  • Takes 6 weeks for bone to be used (at this time hard callus is formed, and casts are removed)