Psychiatry Drugs Antipsychotics Flashcards
What do all typical antipsychotics block?
What are they used for?
D2 receptors.
Also increase cAMP
Used for Schizo, acute mania, Tourettes
What are the typical antipsychotics?
Chlorprozamine Fluphenazine Trifluoperazine Thioridazine Haloperidol Crazy Fools Try The Halos
What are the high potency antipsychotics?
SEs
Try to Fly High
Trifluoperazine
Fluphenazine
Haloperidol
SEs: EPS symptos ie tardive dyskinesia
What are the low potency antipsychotics?
SE
Cheating Thieves are Low (potency)
Chlorpromazine—>Corneal Deposits
Thioridazine—>Retinal Deposits
a1-blocker
anti-Cholinergic, anti-hisTamine
What are the EPS SEs?
4 hours–>acute dystonia (muscle spasm, stiffness)
4 day—> akathesia (restlessness)
4 weeks—>bradykinesia (Parkinsonium)
4 months–> Tardive Dyskinesia
Which drug causes NMS?
Its neuroleptic malignant syndrome Haloperidol causes Symptoms are FEVER Fever Encephalopathy Vitals Unstable Enzymes increased Rigidity of muscles
Toxicity Points for typical antipsychotics
Very lipid soluble, so slow to be removed
EPS ie dyskinesia so use Benzotropine or diphenhydramine
NMS
Endocrine issues bc blocking DA so
–prolactinemia, gynecomastia, amenorrhea
Anticholinergic->Dry mouth, constipation
Antihistamine–>Sedation
a-1 block–>hypotension
What do the atypical antipsychotics block?
What are they used for?
Block 5-HT DA a-1 H1
Schizo both + and - symptoms
BiPolar
OCD
May have lesser SEs then typiclas
What are the atypical antipsychotics?
Olazapine Clozapine Quetipine Risperdone Aripiprazole Ziprasidone
Old Closets quietly risper from A-Z
Clozapine benefits
SEs
Blocks D2c which is in mesolimbic only so no movement probs
ONLY DRUG NOT ASSOC WITH TARDIVE DYSKINESIA
But get Agranulocytosis so have to get weekly CBC (HSR II) must watch clozapine clozely
Increase salivation–wet pillow syndrome due to 5-HT block
Seizures
Quinidine like (Torsade)
Risperdone benefits (atypical( SEs
Increases prolactin–>lactation & gynecomastia
Ziprasidone SEs (atypical)
May prolong QT dangerous in elderly
Aripiprazole (atypical)
Partial DA agonist/Histamine
Musc Antag
Lithium Use
SEs
Mood stabilizer
Can also treat SIADH
SEs: LMNOP Lithium Movement (tremor) Nephrogenic Diabetes Insipidus (ADH antagonist) hypOthyroid Preggo probs (Ebstein Anomaly)
Narrow therapeutic window
Excreted by the kidneys only at prox tubule right behind its cousin Na+
Buspirone
Uses
SEs
For generalized anxiety disorder
Stimulate 5-HT
No SEs really
No sedation, addiction, or tolerance, so no withdrawl. can drink too
Takes a week to start working tho so let ur patient know it will be a while. Can give them alprazolam to have immediate benefits
