Drugs for Trypanosomes Flashcards
1
Q
Drugs for trypansomes
A
Pentamidine Melarsoprol Nifurtimox Suramin Eflornithine
2
Q
Pentamidine
A
Hemolytic stage of infection
No X BBB
3
Q
Melarsoprol
A
Oganic arsenic that inhibits sulfhydryl groups\
Can X BBB
4
Q
Nifurtimox
A
Inhibits enzyme unique to trypanosomes - trypanthione reductase
5
Q
Sumarin
A
DOC for early hemolytic stages
6
Q
Eflornithine
A
Suicide substrate of ornithine decarboxylase