Muscarinic Antagonists Flashcards
What are the muscarinic antagonists?
Atropine, HomATROPINE, TROPIcamide Benztropine Scopalamine Ipratroprium, Tiotropium Oxybutynin, Darifenacin, Solifenacin Glycopyyrolate
Atropine, Homatropine, Tropicamide
MOA
Use?
Works in the eye:
Produce mydriasis and cycloplegia
Antispasmatic, Antisecretory, Antidiarrheal opthalmology
Atropine
MOA
Use
Muscarinic Antagonist (Dry up everything, slow it down and open it up)
Used to treat BRADY and ophthalmic issues Eye: Incr pupil dilation, cycloplegia Airway: Decrease secretions Stomach: Decrease acid secretion Gut: Decrease motility Bladder: Decrease urgency in cystitis
Blocks DUMBBELSS
Works on skeletal muscle at the Nn level, no effect on Nm
SE of Atropine
Increased Body Temp (Hot as a hare) Rapid Pulse Dry mouth, Dry flushed skin (Dry as a bone, Red as a beet) Cycloplegia (blind as a bat) Disorientation (mad as a hatter) Constipation
Can cause acute angle glaucoma in elderly, urinary retention in BPH, hyperthermia in infants
Benztropine
CNS Lipid Soluble
For parkinsons
Scopalamine
CNS
Motion Sickness
Ipratropium, Tiotropium
Respiratory
COPD, Asthma
I PRA I can breathe soon
Oxybutynin, Darifenacin, Solifenacin
GU
Reduce urgency in mild cystitis, reduce bladder spasms
Other drugs that do this are :
Tolterodine
Fesoterodine
Trospium
What other drugs can reduce urinary urgency and bladder spasms?
Tolterodine
Fesoterodine
Trospium
Glycopyrrolate
GI, Respiratory
Preop to reduce airway secretions (so you can do a trach)
Oral: Decrease drooling; peptic ulcer
What are other drugs with anti-muscarinic properties (atropine pharmacology)
Anti-HISTAMINE TCAs Antipsychotics Quinidines Amantadine Meperidine
What drugs block ACh at the neuronal level?
Hexamethamonium
Mecamylamine
Decrease baro reflex by decreasing the predominant autonomic tone
