Psych Pharm

Question 1

Sodium bicarbonate treats overdose of

Answer 1

Amitryptilines

Question 2

What drugs can precipitate lithium toxicity

Answer 2

Thiazides, NSAIDs, ACE Inhibitors

Question 3

Depression, fatigue, Hypersomnia, hyperphagia (excessive eating), vivid dreams are signs of

Answer 3

Cocaine withdrawal

Question 4

The opioid antagonist ______ is first line therapy for moderate to severe alcohol use dependence. How does it affect cravings

Answer 4

naltrexone, decreases them

Question 5

Disulfram blocks ________ and how does it affect cravings

Answer 5

aldehyde dehydrogenase, doesn’t affect them so can only use in someone who is already abstinent patients

Question 6

How does lithium affect the thyroid?

Answer 6

It can lead to hypothryoidism so need to check TSH levels and can give T4 to supplement if necessary (sx: wt. gain, hair loss, dry skin)

Question 7

subjective restlessness with inability to sit still

Answer 7

askathsia

Question 8

involuntary movements after long term antipsychotic use (lip smacking, choreoathetoid movements)

Answer 8

tardive dyskinesia

Question 9

sudden onset sustained muscle contractions

Answer 9

acute dystonia

Question 10

_______ is the MOST PERSISTENT opioid side effect. How is this best to treat?

Answer 10

constipation: tolerance can develop with opioids as you increase the dose but not to constipation and miosis, with adequate fluid intake and daily laxatives

Question 11

IV ______ are first line treatment for status epilepticus (not regaining consciousness between seizures) and what is their MOA?

Answer 11

benzodiazipenes (lorazepam), they act on GABA-A receptor to inc Cl- influx–> suppression of action potential firing

Question 12

Monoamine oxidase inhibitor works by irreversibly binding _________

Answer 12

monoamine oxidase, so when you stop an MAO-i you have to give it couple weeks before starting another drug so monoamine oxidase has time to regenerate and break down serotonin, norepi, dopamine

Question 13

_______ is the drug of choice for treatment resistant schizophrenia. What levels do you need to monitor?

Answer 13

clozapine, check for agrnaulocytosis

Question 14

PCP works as a ________ antagonist. What are sx?

Answer 14

N-methyl-D-aspartate, agitation/hallucinations/strength

Question 15

Treatment for narcolepsy includes _______ which acts as to inc _______

Answer 15

modafinil, dopanergic signaling

is a non-amphetamine stimulant

Question 16

DRESS syndrome symptoms

Answer 16

Inc eosinophilia, systemic skin involvement, fever, general LAD
-from anticonvulsants

Question 17

Long term with levodopa can cause __________ in motor funtion

Answer 17

unpredictable fluctuations

Question 18

stimulus control therapy for sleep

Answer 18

dissociate the bedroom from any stimulating activities that don’t involve sleep

Question 19

sleep hygiene

Answer 19

focuses on the importance of a healthy sleep schedule and the effects of diet, alcohol

Question 20

opioids _____ potassium channels and ____ Ca channels

Answer 20

open, close

Question 21

increased appetite and sleep, leaden paralysis, rejection sensitivity, and mood reactivity are all hallmarks of _________

Answer 21

atypical depression

Question 22

flumazenil reveres ________ but not ________

Answer 22

benzos, barbiturates