Pharmacology General Flashcards
CYP 450 INDUCERS
Chronic Alcoholics Steal Phen Phen & Never Refuse Greasy Carbs
Alcohol St. John’s wort Phenobarbital, Phenytoin Nevirapine Rifampin Griseofulvin Carabamazepine
CYP450 Inhibitors
SICKRFACES.COM
Sodium valproate Isoniazid Cimetidine Ketoconazole Ritonavir Fluconazole Acute alcohol Cloramphenicol Erythromycin Sulfonamides Ciprofloxacin Omeprazole Metronidazole
half life equation
t1/2= (.7 x Vd)/CL
With first order kinetics, what’s the amount of 1/2 lives a drug is excreted
Half lives: amount eliminated
1: 50%
2: 75%
3: 87.5%
4: 93.75%
5: 96%
Following IV administration, highly lipophilic drug will be rapidly distributed to organs with ____ blood flow, and then it is redistributed to organs with _____ blood flow
high (brain, heart, lungs, kidney), low (peripheral: skeletal muscle, fat, bone)
carrier mediated transport includes ____ diffusion and _____ transport
facilitated, active
With _____ order kinetics, the graph levels out to a ____ slope and a _______ amount of drug is metabolized and eliminated per unit of time regardless of dose
zero, zero, constant
-so 10mg of dose is absorbed whether the dose is 20mg or 40mg, etc.
In ______ order kinetics, a constant fraction (or proportion) of the drug is metabolized per unit of time so the amount metabolized depends on the serum concentration
first
maintenance dose
Cpss x CL/ (bioavailability)
loading dose
Cpss x Vd/ (bioavailability)
What is permisiveness
when one drug allows another drug to exert its maximal effect
what is an additive effect?
when the combo of two drugs equals the sum of their effects
What is a synergistic effect?
when combined effect exceeds the sum of the two drugs
What is tachyphylaxis?
dec drug responsiveness in a short period following one or more doses (rapidly developing tolerance)
what is subclavian steal syndrome
when you get stenosis in the subclavian artery and get retrograde flow in the left vertebral artery. If get sx: dizziness, vertigo, drop attacks, diff systolic BP between arms
