Heme pharm

Question 1

Rasburicase

Answer 1

(Also urate oxidase)

Protects against tumor lysis syndrome: convert uric acid into more soluble metabolites (allantoin)

Question 2

Gardos

Answer 2

Tx sickle cell: stops efflux of K+ and water from the cell, preventing dehydration of erythrocytes

Question 3

Drugs that cause aplastic anemia

Answer 3

Chloramphenicol, carbamazepine, sulfonamides

Question 4

How does factor Xa direct inhibitor affect PT, aPTT, thrombin time (TT)?

Answer 4

Because Xa is located at the junction of intrinsic (aPTT) and extrinsic (PT) pathways, it prolongs both PT and aPTT with no effect on TT

Question 5

How do direct thrombin inhibitors affect PT, aPTT, TT?

Answer 5

Prolongs ALL

Question 6

How does amyl nitrate affect hemoglobin treat cyanide poisoning

Answer 6

It makes it into Fe3+ which turns into methehemoglobin and this binds cyanide and removes it from system

Question 7

What does ristocetin test measure

Answer 7

In vitro vWF platelet aggregation so will have no response if vWF deficiency but will when add plasma

-ristocetin activates Gp1b on platelets and makes them able to bind vWF

Question 8

How is heparin induced thrombocytopenia treated

Answer 8

With direct thrombin inhibitors such as ARGATROBAN

Question 9

Sirolimus binds _____ which inhibits ____ and blocks what cytokine?

Answer 9

FK506, mTOR,IL-2

Question 10

______ rapidly reverses warfarins effects while ______ requires time for clotting factor re-synthesis

Answer 10

fresh frozen plasma, vitamin K

Question 11

_________ is an antifibrinolytic agent that inhibits plasminogen activators= helps cause hemostasis when fibrinolysis is the cause of bleeding

Answer 11

aminocaproic acid

Question 12

Patients may receive _______ as treatment for neutropenic fever and this binds a ________ receptor

Answer 12

granulocyte stimulating factor, transmembrane

Question 13

vitamin K facilitates _________ of clotting factors

Answer 13

CARBOXYLATION