PSYC Week 5 Flashcards

1
Q

Differentiate the functional roles between the two main cell classes in the brain, neurons and glia.

A

Neuron
-nerve cells
-dendrite: main input to the neuron
-soma: cell body, contains nucleus/genetic information
-axon: carries action potential to another neuron
-synapse: place where the axon comes to close to another neurons dendrite
-terminal button: end of axon that forms synapse with post-synaptic dendrite
-synaptic vessels: package neurotransmitters

Glia
-form myelin sheath
-digest dead neurons
-nutritional support from blood vessels to neurons
-regulate ionic composition of extracellular fluid

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2
Q

Describe how the forces of diffusion and electrostatic pressure work collectively to facilitate electrochemical communication.

A

maintain steady state of cell
-electrostatic pressure: force on two ions with same charge to repel, or different charges to attract
-have no effect on anions because they are impermeable to cell membrane
-potassium(K+): high concentration in the cell, diffusion pushes them out of the cell and electrostatic pressure pushes K+ into the cell because its attracted to negative charge of the cell
-chloride(Cl-): high concentration out the cell because of electrostatic pressure (opposite K-)
-sodium potassium pump: both forces push Na+ into cell but its impermeable, the ion channel which uses ATP from the neuron to pump 3 Na+ ions out the cell in exchange for bringing in 2 K+ ions

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3
Q

Define resting membrane potential, excitatory postsynaptic potentials, inhibitory postsynaptic potentials, and action potentials.

A

Resting membrane potential
- The voltage inside the cell relative to the voltage outside the cell while the cell is at rest (approximately -70 mV).

Excitatory postsynaptic potentials
- A depolarizing postsynaptic current that causes the membrane potential to become more positive and move towards the threshold of excitation.

Inhibitory postsynaptic potentials
- A hyperpolarizing postsynaptic current that causes the membrane potential to become more negative and move away from the threshold of excitation.

Action potential
- A transient all-or-nothing electrical current that is conducted down the axon when the membrane potential reaches the threshold of excitation.

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4
Q

Explain features of axonal and synaptic communication in neurons.

A

-when a cell becomes depolarized voltage dependent Na+ channels open causing Na+ to rush into the cell making the inside of the cell more positive, Na+ channels then close and refractory period occurs and a new action potential cannot occur until the cell returns to resting membrane potential, K+ channels open up and K+ is driven out of the cell (which causes cell to return to resting membrane potential), very rapid

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5
Q

Axon

A

Part of the neuron that extends off the soma, splitting several times to connect with other neurons; main output of the neuron.

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6
Q

Synapse

A

Junction between the presynaptic terminal button of one neuron and the dendrite, axon, or soma of another postsynaptic neuron.

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7
Q

Electrostatic pressure

A

The force on two ions with similar charge to repel each other; the force of two ions with opposite charge to attract to one another.

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8
Q

Sodium-potassium pump

A

An ion channel that uses the neuron’s energy (adenosine triphosphate, ATP) to pump three Na+ ions outside the cell in exchange for bringing two K+ ions inside the cell.

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9
Q

Synaptic gap

A

Also known as the synaptic cleft; the small space between the presynaptic terminal button and the postsynaptic dendritic spine, axon, or soma.

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10
Q

Synaptic vesicles

A

Groups of neurotransmitters packaged together and located within the terminal button.

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11
Q

Define the basic terminology and basic principles of hormone–behavior interactions.

A

-hormones: organic chemical messengers produced and released by endocrine glands
-target cells: cells with specific receptors for hormones
-hormones can mediated long term developments like growth, development, and reproduction

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12
Q

Explain the role of hormones in behavioral sex differentiation.

A

-testosterone: primary androgen (group of hormones that play a role in male traits and reproductive activity) found in mens testes
-typically female behaviour requires a lack of exposure to androgens in early life
-gondal sex: determined by ovaries and testes

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13
Q

Explain the role of hormones in aggressive behavior.

A

-evidence that androgenic steroid hormones mediate aggressive behaviour across many species
-higher blood concentration of androgens could be an explanation as to why men are more aggressive

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14
Q

Explain the role of hormones in parental behavior.

A

-progesterone: involved in pregnancy and mating behaviours
-parental behaviour is caused by hormones
-woman with high cortisol levels before nursing engaged in more talking and physically affectionate behaviours with their babies

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15
Q

Provide examples of some common hormone–behavior interactions.

A

behavior interactions -the mediation of food and fluid intake
social interactions– salt balance, learning and memory, stress coping, as well as psychopathology including depression, anxiety disorders, eating disorders, postpartum depression, and seasonal depression

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16
Q

Neurotransmitter

A

A chemical messenger that travels between neurons to provide communication. Some neurotransmitters, such as norepinephrine, can leak into the blood system and act as hormones.

17
Q

5α-reductase

A

An enzyme required to convert testosterone to 5α-dihydrotestosterone.

18
Q

Dihydrotestosterone (DHT)

A

A primary androgen that is an androgenic steroid product of testosterone and binds strongly to androgen receptors.

19
Q

How do the majority of psychoactive drugs work in the brain?

A

-interfere with how neurons communicate with each other
-agonists: increase activity at synapse
-antagonists: decrease activity at synapse

20
Q

How does the route of administration affect how rewarding a drug might be?

A

-interfere with how neurons communicate with each other
-agonists: increase activity at synapse
-antagonists: decrease activity at synapse

21
Q

Why is grapefruit dangerous to consume with many psychotropic medications?

A

-grapefruit juice suppresses P450 enzymes that break down drugs
-can lead to toxic concentrations

22
Q

Why might individualized drug doses based on genetic screening be helpful for treating conditions like depression?

A

-would give insight on how much to prescribe based on how fast the individuals body breaks down the drug

23
Q

Why is there controversy regarding pharmacotherapy for children, adolescents, and the elderly?

A

-the brain continues to develop until you are 20 years old, it is worried that drugs that affect neural activity in the brain could have consequences
-evidence drugs can decrease bone density which is unsafe for the elderly
-metabolism is often slowed in the elderly which means the side effects of drugs could be more intense