Proteins synthesis inhibitors

Question 1

Ribosome contains?

Answer 1

Ribosomal RNA (rRNA)
Protein

Question 2

What are the 2 subunits of ribosome?

Answer 2

50S and 30S

Question 3

30S Subunit contains how many rRNA and proteins?

Answer 3

16S and 21 proteins

Question 4

50S Subunit contains how many rRNA and proteins?

Answer 4

5S and 23S with 31 proteins

Question 5

What is the unit for Ribosome?

Answer 5

Svedberg unit

Question 6

What RNA is in 50S?

Answer 6

tRNA (Transmission RNA)-antisen

Question 7

What RNA is in 30S?

Answer 7

mRNA (Messenger RNA)

Question 8

NOTE: Protein synthesis inhibitors inhibits ribosome (50S and 30S)

Question 9

Example of aminoglycosides

Answer 9

ToAG KaS

Tobramycin
Amikacin
Gentamicin
Kanamycin
Streptomycin

Question 10

Example of Macrolides?

Answer 10

Erythromycin
Azithromycin
Clarithromycin

Question 11

Example of Lincosamide?

Answer 11

Clindamycin and Lincomycin

Question 12

Aminoglycosides derives from what bacteria?

Answer 12

Micromonospora spp.

Question 13

Macrolides derives from what bacteria?

Answer 13

saccharopolyspora erythraea
Streptomyces ambofaciens

Question 14

Lincosamide derives from what bacteria?

Answer 14

Streptomyces lincolnensis

Question 15

M. tuberculosis is the spectrum of disease

Answer 15

Aminoglycosides

Question 16

Gram positive Atypical bacteria is the spectrum of disease

Answer 16

Macrolides

Question 17

Gram positive cocci clindamycin is the spectrum of acitvities

Answer 17

Lincosamide

Question 18

Inhibit proteins by binding 2 sites on 50S ?

Answer 18

Streptogramins

Question 19

Example of streptogramins

Answer 19

Quinupristin

Question 20

Example of phenicols?

Answer 20

Chloramphenicol

Question 21

Phenicols is derive from what bacteria?

Answer 21

Streptomyces venezuelae

Question 22

Spectrum of activities for fastidious organisms

Answer 22

Phenicols

Question 23

Tetracycline derive from?

Answer 23

Streptomyes aureofaciens and rimosus

Question 24

Binds to 30S

Interrupts Initial formation of Protein synthesis complex, reading and formation for mRNA

Answer 24

Aminoglycoside

Question 25

Binding to the 23S ribosomal RNA on the bacterial 50S ribosomal subunit

subsequent disruption of the growing peptide chain by blocking of TRANSLOCATION

Answer 25

Macrolides

Question 26

Bind to the 50s

Prevents Elongation by interfering with peptidyl transfer

Answer 26

Lincosamides

Question 27

Bind irreversibly to 50S

Induces conformational change in the ribosome

Answer 27

Streptogramins

Question 28

23S RNA in the 50S

Inhibit 70S initiation complex formation and blocking translation of any mRNA

Answer 28

Oxazolidinones

Question 29

50S

Inhibits the addition of amino acids

Inhibits TRANSPEPTIDATION

Answer 29

Chloramphenicol

Question 30

Binds irreversibly in 30S

Prevents peptide chain elongation in tRNA

Answer 30

Tetracycline

Question 31

Side effect of chloramphenicol?

Answer 31

Aplastic anemia

Question 32

Side effects that includes uppergastric toxicity

Answer 32

tetracycline