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Bacte Lab (Finals > Proteins synthesis inhibitors > Flashcards

Proteins synthesis inhibitors Flashcards

1
Q

Ribosome contains?

A

Ribosomal RNA (rRNA)
Protein

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2
Q

What are the 2 subunits of ribosome?

A

50S and 30S

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3
Q

30S Subunit contains how many rRNA and proteins?

A

16S and 21 proteins

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4
Q

50S Subunit contains how many rRNA and proteins?

A

5S and 23S with 31 proteins

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5
Q

What is the unit for Ribosome?

A

Svedberg unit

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6
Q

What RNA is in 50S?

A

tRNA (Transmission RNA)-antisen

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7
Q

What RNA is in 30S?

A

mRNA (Messenger RNA)

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8
Q

NOTE: Protein synthesis inhibitors inhibits ribosome (50S and 30S)

A
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9
Q

Example of aminoglycosides

A

ToAG KaS

Tobramycin
Amikacin
Gentamicin
Kanamycin
Streptomycin

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10
Q

Example of Macrolides?

A

Erythromycin
Azithromycin
Clarithromycin

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11
Q

Example of Lincosamide?

A

Clindamycin and Lincomycin

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12
Q

Aminoglycosides derives from what bacteria?

A

Micromonospora spp.

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13
Q

Macrolides derives from what bacteria?

A

saccharopolyspora erythraea
Streptomyces ambofaciens

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14
Q

Lincosamide derives from what bacteria?

A

Streptomyces lincolnensis

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15
Q

M. tuberculosis is the spectrum of disease

A

Aminoglycosides

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16
Q

Gram positive Atypical bacteria is the spectrum of disease

A

Macrolides

17
Q

Gram positive cocci clindamycin is the spectrum of acitvities

A

Lincosamide

18
Q

Inhibit proteins by binding 2 sites on 50S ?

A

Streptogramins

19
Q

Example of streptogramins

A

Quinupristin

20
Q

Example of phenicols?

A

Chloramphenicol

21
Q

Phenicols is derive from what bacteria?

A

Streptomyces venezuelae

22
Q

Spectrum of activities for fastidious organisms

A

Phenicols

23
Q

Tetracycline derive from?

A

Streptomyes aureofaciens and rimosus

24
Q

Binds to 30S

Interrupts Initial formation of Protein synthesis complex, reading and formation for mRNA

A

Aminoglycoside

25
Q

Binding to the 23S ribosomal RNA on the bacterial 50S ribosomal subunit

subsequent disruption of the growing peptide chain by blocking of TRANSLOCATION

A

Macrolides

26
Q

Bind to the 50s

Prevents Elongation by interfering with peptidyl transfer

A

Lincosamides

27
Q

Bind irreversibly to 50S

Induces conformational change in the ribosome

A

Streptogramins

28
Q

23S RNA in the 50S

Inhibit 70S initiation complex formation and blocking translation of any mRNA

A

Oxazolidinones

29
Q

50S

Inhibits the addition of amino acids

Inhibits TRANSPEPTIDATION

A

Chloramphenicol

30
Q

Binds irreversibly in 30S

Prevents peptide chain elongation in tRNA

A

Tetracycline

31
Q

Side effect of chloramphenicol?

A

Aplastic anemia

32
Q

Side effects that includes uppergastric toxicity

A

tetracycline

Bacte Lab (Finals (13 decks)

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