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Pharma ๐ŸŸฃ > Protein synthesis inhibitors > Flashcards

Protein synthesis inhibitors Flashcards

1
Q

What is the Pharmacokinetics of aminoglycoside ?

A

1- Not absorbed orally
2- Neomycin is not given parenterally
3- or orally for bowel preparation prior to colorectal surgery
3- no CNS penetration

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2
Q

Why we are preferring the use of single large daily dose of aminoglycosides ?

A

1- Bacteria killing effect of aminoglycosides depends on peak plasma concentration
2- Post antibiotic effect

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3
Q

What is the uses of aminoglycosides ?

A

1- Serious gram negative bacillary infection such as Escherichia coli
2- Staph.aureus infection
3- Eradication of facultative gut flora
4- Cystic fibrosis

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4
Q

What is the adverse effects of aminoglycosides ? ( Non )

A

1- Nephrotoxicity
2- ototoxicity
3- Neuromuscular blockade

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5
Q

What is the drug that has a half-life of 36 hours ?

A

Tigecycline

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6
Q

Doxycycline and Minocyclinene is absorped -95-100% and it is ?

A

No food interaction

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7
Q

Avoid antacids or dairy products along with ?

A

tetracyclines or give 1-3 hours apart

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8
Q

What is the drug that attains high concentration in tears and saliva and suitable for the treatment of meningococcal carrier state ?

A

Minocycline

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9
Q

Minocycline is uses for ?

A

meningococcal carrier state

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10
Q

What is the contra indication of Tetracycline ?

A

during pregnancy and lactation

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11
Q

What is the drug that contraindicated during pregnancy and lactation ?

A

Tetracycline

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12
Q

What is the Adverse effects of Tetracycline ?

A

1- Effects on calcified tissues (Teeth and bones)
2- Fanconi Syndrome
3- Fatal hepatotoxicity

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13
Q

Whatvis the Contraindications of tetracyclines ?

A

1- pregnant
2- breast-feeding women
3- children less than 8 years

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14
Q

What is the drug that has a half-life of 36 hours ?

A

Tigecycline

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15
Q

In the Pharmacokinetics of Tetracyclines the Doxycycline and Minocycline -95-100% is ?

A

No food interaction

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16
Q

What is the products that must Avoid with tetracyclines ?

A

Avoid antacids or dairy products

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17
Q

Avoid antacids or dairy products along with tetracyclines or give ?

A

1-3 hours apart

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18
Q

What is the drug of meningococcal carrier state ?

A

Minocycline

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19
Q

Minocycline attains high concentration in tears and saliva and suitable for the treatment of ?

A

meningococcal carrier state

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20
Q

What is the drug that preferred in patients with renal

dysfunction, as it is primarily eliminated via the bile into the feces ?

A

Doxycycline

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21
Q

What is the Clinical uses of Tetracyclines ? ุญู‚ุช ูƒุฑูƒู… ุจุงุดุง

A

1- chlamydiae
2- rickettsiae
3- cholera
4- brucellosis

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22
Q

What is the adverse effects of tetracyclines ?

A

1- Fanconi Syndrome
2- Effects on calcified tissues (Teeth and bones)
3- Fatal hepatotoxicity

23
Q

What is the Adverse effects of Tigecycline ?

A

1- Pancreatitis

2- Hepatotoxicity

24
Q

Chloramphenicol ?

A

Binds reversibly to the 50S ribosomal subunit .

25
Q

What is the Clinical uses of chloramphenicol ?

A

Fever,headache,Rash,Nauea.,vomiting,

26
Q

What is the Adverse effects of chloramphenicol ? ุฌุจุณ

A

1- Grey baby syndrome
2- GIT disturbances
3- Bone marrow depression
4- Superinfection

27
Q

In the Erythromycin Pharmacokinetics the drug is distributed widely except to the ?

A

brain and cerebrospinal fluid

28
Q

It cross the placenta and reaches the fetus ?

A

Erythromycin

29
Q

What is the Clinical uses of Erythromycin ?

A

1- Alternative to penicillin in hypersensitive patients

2- Acne (topical)

30
Q

What is the drug is safest for the treatment of MRSA in a pregnant patient ?

A

Clindamycin

31
Q

What is the Adverse effects of Clindamycin ?

A

Pseudo-membraneous colitis (Clostridium difficileโ€“associated diarrhea )

32
Q

They inhibiting the formation of the 70S ?

A

Linezolid and tedizolid

33
Q

What is the drug that does have coverage against resistant S. pneumoniae ?

A

Linezolid

34
Q

We use aminoglycosides in Endocarditis with ?

A

ampicillin/ vancomycin

35
Q

We use aminoglycosides in Meningitis in ?

A

1- combination with cell wall synthesis inhibitors

2- intrathecal/ intraventricular

36
Q

aminoglycosides is Contraindicated in patients with ?

A

Myasthenia gravis, Hypocalcaemia

37
Q

Bind 30 s ribosomal subunit ?

A

1- aminoglycosides

2- Tetracycline

38
Q

What is the Mechanism of Action of Tetracyclines ?

A

1- Binds reversibly to 30S ribosomal subunit

2- Blocks binding of tRNA to the acceptor site and inhibits protein synthesis

39
Q

What is the drug of tetracyclines ?

A

Tetracycline, Oxytetracycline, Doxycycline

40
Q

What is the Short-acting of tetracycline ?

A

1- tetracycline

2- chlortetracycline

41
Q

What is the Intermediate-acting of tetracycline ?

A

1- demeclocycline

2- methacycline

42
Q

What is the Long-acting of tetracycline ?

A

1- doxycycline

2- minocycline

43
Q

Uses of Tetracyclines ?

A 
ูƒุฑูƒู… ุจุงุดุง 
1- chlamydiae
2- rickettsiae
3- cholera
4- brucellosis
44
Q

Binds reversibly to the 50S ribosomal subunit ?

A

Chloramphenicol

45
Q

Grey baby syndrome is the Adverse effects of ?

A

chloramphenicol

46
Q

Binds with 50S ribosome ?

A

1- Macrolides

2- Clindamycin

47
Q

inhibiting the formation of the 70S ?

A

Linezolid and tedizolid

48
Q

What is the contraindication of erythromycin !

A

Hepatic dysfunction

49
Q

Erythromycin is an inhibitor of ?

A

Hepatic microsomal CYP-450

50
Q

What is the drug that combination with non absorbable erythromycin ?

A

Neomycin

51
Q

What is the drug that reduces colonization of

Pseudomonas L

A

Daily inhalation of Tobramycin

52
Q

What is the Adverse effects of aminoglycosides ?

A

1- Nephrotoxicity
2- ototoxicity
3- Neuromuscular blockade
4- Contraindicated in patients with : Myasthenia gravis, Hypocalcaemia

53
Q

Erythromycin is an inhibitor of hepatic microsomal ?

A

CYP-450

Pharma ๐ŸŸฃ (15 decks)

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