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Adrenergic drugs مهم Flashcards

1
Q

Epinephrine (Adrenaline) is Stimulates ?

A

( a1 , a2 , B1 , B2 , B3 )

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2
Q

Norepinephrine ?

A

( a1 , a2 , β1 )

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3
Q

Isoproterenol (isoprenaline) ? ابو التوأم الدب

A

( β1, β2 )

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4
Q

Dopamine الدب أمين ?

A

1- In small dose acts on D1 ( increase renal
blood flow & V.D. )
2- In moderate dose acts on (D1 & B1)
3- In large dose acts on (a1 ) V. C.

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5
Q

Dobutamine دبه امين = زوجته ?

A

Selective B1 agonist.

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6
Q

Phenylephrine ?

A

selective a1 antagonist

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7
Q

Oxymetazoline ?

A

α1& α2-adrenergic

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8
Q

Give examples of Selective a2 agonists ?

A

Clonidine and a- Methyldopa

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9
Q

Selective B2 agonists ?

A

Albuterol, salbutamol & terbutaline

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10
Q

Selective B3 agonists ?

A

Mirabegron

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11
Q

What is the Absorption of epinephrine ?

A

ineffective orally غير فعال فمويا

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12
Q

What is the uses of epinephrine

A 
1- anaphylactic shock S.C. or IV 
2- Cardiac arrest 
3- epistaxis
4- With local anesthetics 
5- open angle glaucoma
6- acute sever asthma
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13
Q

What is the Adverse effect of epinephrine ?

A

1- cerebral haemorrhages

2- cardiac arrhythmia

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14
Q

What is the Contraindications of epinephrine ?

A

1- Cardiovascular disease
2- Hypertension
3- Hyperthyroidism
4- Diabetes mellitus

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15
Q

Norepinephrine Act mainly on ?

A

alpha receptors more than beta receptors

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16
Q

What is the Pharmacological actions of Norepinephrine ?

A

1- Blood vessels (V.C.) due to alpha 1

2- Heart : Reflex bradycardia

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17
Q

What is the uses of Norepinephrine (a1,a2,B1 ) ?

A

Shock to treat acute hypotension

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18
Q

What is the uses of Dopamine ?

A

Fenoldopam (selective D1 agonist) used in ttt of hypertensive emergency

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19
Q

Fenoldopam (selective D1 agonist) used in ttt of ?

A

hypertensive emergency

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20
Q

What is the Side effects& contraindications of Dobutamine ?

A

It should be used with caution in atrial fibrillation

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21
Q

What is the drug that is less potent than noradrenalin in raising blood pressure but it
has a more prolonged action ?

A

Phenylephrine

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22
Q

Phenylephrine ( a1 ) is leads to ?

A

reflex bradycardia

23
Q

What is the Therapeutic uses of Phenylephrine ( selective a1 agonist ) ?

A

1- nasal decongestant
2- Hypotension
3-ophthalmology to produce pupillary dilation (mydriasis)

24
Q

What is the Adverse effect of phenylephrine ?

A

1- cardiac irregularity& hypertension.

2- Rebound nasal congestion

25
Q

Give example of Selective a2 agonists ?

A

Clonidine and a- Methyldopa

26
Q

What is the uses of Selective a2 agonists ?

A

1- treatment of hypertension

2- minimize the symptoms that accompany withdrawal from opiates, tobacco smoking

27
Q

What is the drug that used intratment of hypertension in pregnancy ?

A

a Methyldopa

28
Q

used intratment of hypertension in pregnancy ?

A

a - Methyldopa

29
Q

Selective B2 agonists ?

A

1- Albuterol
2- salbutamol
3- terbutaline

30
Q

Selective B2 agonists used in ?

A

bronchial asthma

31
Q

Terbutaline is also used as a ?

A

uterine relaxant

32
Q

What is the B2 activation relax the pregnant uterus ?

A

1- Ritodrine

2- terbutaline

33
Q

What is the drug that mood-elevating (euphoriant) effect ?

A

Amphetamine

34
Q

What is the powerful cardiac stimulant ?

A

Epinephrine

35
Q

What is the powerful cardiac stimulant ?

A

Epinephrine (Adrenaline)

36
Q

Injection of epinephrine, increases the?

A

systolic pressure but the diastolic pressure usually falls

37
Q

What is the uses of Norepinephrine ?

A

Shock to treat acute hypotension

38
Q

What is the Examples of selective a2 agonists ?

A

Clonidine and a- Methyldopa

39
Q

What is the uses of b2 agonists ?

A

1- bronchial asthma

2- uterine relaxant

40
Q

Ritodrine is selective ?

A

B2 agonist ( has relaxant effect on the uterus)

41
Q

What is the uses of Ritodrine ?

A

has relaxant effect on the uterus

42
Q

What is the uses of selective B3 agonists ?

A

used for patients with overactive bladder.

43
Q

What is the uses of Mirabegron ?

A

used for patients with overactive bladder.

44
Q

What is the function of Amphetamine ?

A

increase in nonvesicular release

45
Q

What is the drug that treat Attention deficit hyperactivity disorder ?

A

Methylphenidate

46
Q

What is the function of Cocaine ?

A

ability to block the sodium-chloride

47
Q

Example of mixed-action agonists ?

A

Ephedrine & pseudoephedrine

48
Q

What is the uses of mixed-action agonists ?

A

1- bronchial asthma

2- nasal decongestant

49
Q

What is the drugs that Treatment of acute hypotension ?

A

1- norepinephrine
2- phenylephrine
3- methoxamine

50
Q

What is the drugs for Cardiogenic shock and acute heart failure ?

A

1- Dopamine

2- Dobutamine

51
Q

What is the drugs for Bronchial asthma ?

A

1- albuterol
2- salbutamol
3- terbutaline
4- formeterol

52
Q

What is the drugs that activation relax the pregnant uterus. (B2) ?

A

1- Ritodrine

2- terbutaline

53
Q

What is the drug that used for mood-elevating (euphoriant) effect ?

A

Amphetamine

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