Adrenergic drugs مهم Flashcards

1
Q

Epinephrine (Adrenaline) is Stimulates ?

A

( a1 , a2 , B1 , B2 , B3 )

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2
Q

Norepinephrine ?

A

( a1 , a2 , β1 )

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3
Q

Isoproterenol (isoprenaline) ? ابو التوأم الدب

A

( β1, β2 )

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4
Q

Dopamine الدب أمين ?

A

1- In small dose acts on D1 ( increase renal
blood flow & V.D. )
2- In moderate dose acts on (D1 & B1)
3- In large dose acts on (a1 ) V. C.

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5
Q

Dobutamine دبه امين = زوجته ?

A

Selective B1 agonist.

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6
Q

Phenylephrine ?

A

selective a1 antagonist

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7
Q

Oxymetazoline ?

A

α1& α2-adrenergic

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8
Q

Give examples of Selective a2 agonists ?

A

Clonidine and a- Methyldopa

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9
Q

Selective B2 agonists ?

A

Albuterol, salbutamol & terbutaline

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10
Q

Selective B3 agonists ?

A

Mirabegron

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11
Q

What is the Absorption of epinephrine ?

A

ineffective orally غير فعال فمويا

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12
Q

What is the uses of epinephrine

A
1- anaphylactic shock S.C. or IV 
2- Cardiac arrest 
3- epistaxis
4- With local anesthetics 
5- open angle glaucoma
6- acute sever asthma
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13
Q

What is the Adverse effect of epinephrine ?

A

1- cerebral haemorrhages

2- cardiac arrhythmia

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14
Q

What is the Contraindications of epinephrine ?

A

1- Cardiovascular disease
2- Hypertension
3- Hyperthyroidism
4- Diabetes mellitus

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15
Q

Norepinephrine Act mainly on ?

A

alpha receptors more than beta receptors

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16
Q

What is the Pharmacological actions of Norepinephrine ?

A

1- Blood vessels (V.C.) due to alpha 1

2- Heart : Reflex bradycardia

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17
Q

What is the uses of Norepinephrine (a1,a2,B1 ) ?

A

Shock to treat acute hypotension

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18
Q

What is the uses of Dopamine ?

A

Fenoldopam (selective D1 agonist) used in ttt of hypertensive emergency

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19
Q

Fenoldopam (selective D1 agonist) used in ttt of ?

A

hypertensive emergency

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20
Q

What is the Side effects& contraindications of Dobutamine ?

A

It should be used with caution in atrial fibrillation

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21
Q

What is the drug that is less potent than noradrenalin in raising blood pressure but it
has a more prolonged action ?

A

Phenylephrine

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22
Q

Phenylephrine ( a1 ) is leads to ?

A

reflex bradycardia

23
Q

What is the Therapeutic uses of Phenylephrine ( selective a1 agonist ) ?

A

1- nasal decongestant
2- Hypotension
3-ophthalmology to produce pupillary dilation (mydriasis)

24
Q

What is the Adverse effect of phenylephrine ?

A

1- cardiac irregularity& hypertension.

2- Rebound nasal congestion

25
Give example of Selective a2 agonists ?
Clonidine and a- Methyldopa
26
What is the uses of Selective a2 agonists ?
1- treatment of hypertension | 2- minimize the symptoms that accompany withdrawal from opiates, tobacco smoking
27
What is the drug that used intratment of hypertension in pregnancy ?
a Methyldopa
28
used intratment of hypertension in pregnancy ?
a - Methyldopa
29
Selective B2 agonists ?
1- Albuterol 2- salbutamol 3- terbutaline
30
Selective B2 agonists used in ?
bronchial asthma
31
Terbutaline is also used as a ?
uterine relaxant
32
What is the B2 activation relax the pregnant uterus ?
1- Ritodrine | 2- terbutaline
33
What is the drug that mood-elevating (euphoriant) effect ?
Amphetamine
34
What is the powerful cardiac stimulant ?
Epinephrine
35
What is the powerful cardiac stimulant ?
Epinephrine (Adrenaline)
36
Injection of epinephrine, increases the?
systolic pressure but the diastolic pressure usually falls
37
What is the uses of Norepinephrine ?
Shock to treat acute hypotension
38
What is the Examples of selective a2 agonists ?
Clonidine and a- Methyldopa
39
What is the uses of b2 agonists ?
1- bronchial asthma | 2- uterine relaxant
40
Ritodrine is selective ?
B2 agonist ( has relaxant effect on the uterus)
41
What is the uses of Ritodrine ?
has relaxant effect on the uterus
42
What is the uses of selective B3 agonists ?
used for patients with overactive bladder.
43
What is the uses of Mirabegron ?
used for patients with overactive bladder.
44
What is the function of Amphetamine ?
increase in nonvesicular release
45
What is the drug that treat Attention deficit hyperactivity disorder ?
Methylphenidate
46
What is the function of Cocaine ?
ability to block the sodium-chloride
47
Example of mixed-action agonists ?
Ephedrine & pseudoephedrine
48
What is the uses of mixed-action agonists ?
1- bronchial asthma | 2- nasal decongestant
49
What is the drugs that Treatment of acute hypotension ?
1- norepinephrine 2- phenylephrine 3- methoxamine
50
What is the drugs for Cardiogenic shock and acute heart failure ?
1- Dopamine | 2- Dobutamine
51
What is the drugs for Bronchial asthma ?
1- albuterol 2- salbutamol 3- terbutaline 4- formeterol
52
What is the drugs that activation relax the pregnant uterus. (B2) ?
1- Ritodrine | 2- terbutaline
53
What is the drug that used for mood-elevating (euphoriant) effect ?
Amphetamine