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Pharma ๐ŸŸฃ > Antiviral agents > Flashcards

Antiviral agents Flashcards

1
Q

Adamantane antivirals ?

A

1- Amantadine

2- rimantadine

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2
Q

Neuaminidase inhibitors ?

A

1- oseltamivir

2- zanamivir

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3
Q

used in parkinsonism (pass BBB) ?

A

Amantadine

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4
Q

Amantadine & rimantadine block the ?

A

M2 ion channel

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5
Q

What is the drug of choice in bird flu strain H5N1 & swine flu strain H1N1 ?

A

Oseltamivir

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6
Q

Zanamavir is contraindicated in ?

A

asthmatic patient

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7
Q

Treatment of choice in herpes simplex encephalitis ?

A

Acyclovir

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8
Q

What is the drug of choice in CMV ?

A

ganciclovir

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9
Q

Drug of choice in chronic HBV ?

A

Entecavir

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10
Q

Interferon alpha is ?

A

Broad spectrum antiviral

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11
Q

Lepromin test is Positive in ?

A

Tuberculoid leprosy

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12
Q

Lepromin test is Negative in ?

A

Lepromatous leprosy

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13
Q

chronic infective venereal disease (Sexually Transmitted Disease, STDs)
caused by Treponema pallidum spirochaetes ?

A

SYPHILIS

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14
Q

Congenital Syphilis is Due to ?

A

transplacental transmission

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15
Q

What is the mechanism of Acyclovir ?

A

inhibits viral DNA polymerase

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16
Q

ganciclovir is contraindicated in ?

A

pregnancy

17
Q

What is the adverse effect of Cidofovir ?

A

nephrotoxicity

18
Q

What is the drug that used in HSV keratitis and conjunctivitis given as eye drops ?

A

1- idoxuridine

2- trifluridine

19
Q

What is the mechanism of Ribavirin ?

A

โ†“ RNA dependent RNA polymerase.

20
Q

Ribavirin used in ?

A

respiratory viral infections and pneumonia (RSV)

21
Q

Waht is the side effect of Ribavirin ?

A

1- hemolytic anemia

2- hepatotoxicity (elevated bilirubin)

22
Q

Ribavirin is Contraindicated in ?

A

pregnancy

23
Q

What is the mechanism of Entecavir ?

A

โ†“ HBV viral DNA polymรฉrase (reverse transcription).

24
Q

What is the uses of Entecavir ?

A

Drug of choice in chronic HBV

25
Q

Interferon alpha is ?

A

Pegylated interferon has longer duration

26
Q

What is the adverse effect of Interferon alpha ?

A

Bone marrow suppression

Pharma ๐ŸŸฃ (15 decks)

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