Antiviral agents Flashcards
Adamantane antivirals ?
1- Amantadine
2- rimantadine
Neuaminidase inhibitors ?
1- oseltamivir
2- zanamivir
used in parkinsonism (pass BBB) ?
Amantadine
Amantadine & rimantadine block the ?
M2 ion channel
What is the drug of choice in bird flu strain H5N1 & swine flu strain H1N1 ?
Oseltamivir
Zanamavir is contraindicated in ?
asthmatic patient
Treatment of choice in herpes simplex encephalitis ?
Acyclovir
What is the drug of choice in CMV ?
ganciclovir
Drug of choice in chronic HBV ?
Entecavir
Interferon alpha is ?
Broad spectrum antiviral
Lepromin test is Positive in ?
Tuberculoid leprosy
Lepromin test is Negative in ?
Lepromatous leprosy
chronic infective venereal disease (Sexually Transmitted Disease, STDs)
caused by Treponema pallidum spirochaetes ?
SYPHILIS
Congenital Syphilis is Due to ?
transplacental transmission
What is the mechanism of Acyclovir ?
inhibits viral DNA polymerase
ganciclovir is contraindicated in ?
pregnancy
What is the adverse effect of Cidofovir ?
nephrotoxicity
What is the drug that used in HSV keratitis and conjunctivitis given as eye drops ?
1- idoxuridine
2- trifluridine
What is the mechanism of Ribavirin ?
β RNA dependent RNA polymerase.
Ribavirin used in ?
respiratory viral infections and pneumonia (RSV)
Waht is the side effect of Ribavirin ?
1- hemolytic anemia
2- hepatotoxicity (elevated bilirubin)
Ribavirin is Contraindicated in ?
pregnancy
What is the mechanism of Entecavir ?
β HBV viral DNA polymΓ©rase (reverse transcription).
What is the uses of Entecavir ?
Drug of choice in chronic HBV
Interferon alpha is ?
Pegylated interferon has longer duration
What is the adverse effect of Interferon alpha ?
Bone marrow suppression
