Fluoroquinolones Flashcards
What is the Clinical uses of fluoroquinolones ?
1- Urinary tract infection 2- Typhoid fever 3- Osteomyelitis 4- Diabetic foot infections 5- peritonitis
What is the Adverse effects of fluoroquinolones ?
1- QTc prolongation
2- Growing cartilage damage and arthropathy in
children
3- Tendinitis in adults
What is the Adverse effects of fluoroquinolones in children ?
Growing cartilage damage and arthropathy
What is the Adverse effects of fluoroquinolones in adults ?
Tendinitis
What is the Contraindication of fluoroquinolones ?
1- QT interval prolongation
2- Severe hepatic functional impairment
3- during pregnancy and lactation
4- Renal function impairment (Moxifloxacin safe in renal imparment
5- Not recommended for age less than 18 years
What is the drug that safe in renal imparment ?
Moxifloxacin
What is the drug of fluoroquinolones that non-renal excretion; no dose adjustment required in renal functional impairment ?
Moxifloxacin
What is the uses of fluoroquinolones ?
1- Urinary tract infection 2- Typhoid fever 3- Osteomyelitis 4- Diabetic foot infections 5- peritonitis 6- Drug of choice for prophylaxis and treatment of anthrax
What is the drug of choice for prophylaxis and treatment of anthrax ?
fluoroquinolones
What is the Adverse effects of fluoroquinolones ?
1- QTc prolongation
2-Growing cartilage damage and arthropathy in
children
3- Tendinitis in adults
Ciprofloxacin is an ?
Inhibitor of CYP 1A2
What is the Contraindication of fluoroquinolones ?
1- QT interval prolongation
2- Severe hepatic functional impairment
3- during pregnancy and lactation
4- Renal function impairment (Moxifloxacin safe in renal imparment
5- Not recommended for age less than 18 years
What is the drug that safe in renal imparment ?
Moxifloxacin
What is tha drug Not recommended for age less than 18 years ?
fluoroquinolones
What is the drug should not be used in children less than 8 years of age ?
tetracyclines
What is the Mechanismof action of Sulfonamides ?
Inhibits dihydropetroate synthase
What is the uses of sulfonamides ?
1- Orally absorbable agents
2- Orally non- absorbable agents like sulfasalazine areuseful for the treatment of ulcerative colitis
3- Topical sulfonamides
What is the drug is Orally non- absorbable taht useful for the treatment of ulcerative colitis ?
sulfasalazine
What is the drug that used in Trachoma and bacterial conjuctivits ?
sulfacetamide
What is the drug that used in Burn dressing ?
Silver sulfadiazine
What is the Adverse effects of sulfonamides ?
1- Crystalluria
2- Steven Johnson syndrome
3- Hemolysis in patients with G6PD enzyme deficiency
4- Kernicterus
What is the Mechanismof action of Trimethoprim ?
Inhibits dihydrofolate reductase
What is the uses of trimethoprim ?
Pneumocystis pneumonia
What is the drug of Pneumocystis pneumonia ?
trimethoprim
Pyrimethamine and sulfadiazine are used in the
treatment of ?
toxoplasmosis
What is the combination of the drugs that used for falciparum malaria ?
pyrimethamine with sulfadoxine
What is the Mechanism of action of Sulfonamides ?
Inhibits dihydropetroate synthase
What is the Mechanism of action of Trimethoprim ?
Inhibits dihydrofolate reductase
