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Pharma 🟣 > Fluoroquinolones > Flashcards

Fluoroquinolones Flashcards

1
Q

What is the Clinical uses of fluoroquinolones ?

A 
1- Urinary tract infection
2- Typhoid fever
3- Osteomyelitis
4- Diabetic foot infections
5- peritonitis
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2
Q

What is the Adverse effects of fluoroquinolones ?

A

1- QTc prolongation
2- Growing cartilage damage and arthropathy in
children
3- Tendinitis in adults

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3
Q

What is the Adverse effects of fluoroquinolones in children ?

A

Growing cartilage damage and arthropathy

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4
Q

What is the Adverse effects of fluoroquinolones in adults ?

A

Tendinitis

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5
Q

What is the Contraindication of fluoroquinolones ?

A

1- QT interval prolongation
2- Severe hepatic functional impairment
3- during pregnancy and lactation
4- Renal function impairment (Moxifloxacin safe in renal imparment
5- Not recommended for age less than 18 years

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6
Q

What is the drug that safe in renal imparment ?

A

Moxifloxacin

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7
Q

What is the drug of fluoroquinolones that non-renal excretion; no dose adjustment required in renal functional impairment ?

A

Moxifloxacin

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8
Q

What is the uses of fluoroquinolones ?

A 
1- Urinary tract infection
2- Typhoid fever
3- Osteomyelitis
4- Diabetic foot infections
5- peritonitis
6- Drug of choice for prophylaxis and treatment of anthrax
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9
Q

What is the drug of choice for prophylaxis and treatment of anthrax ?

A

fluoroquinolones

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10
Q

What is the Adverse effects of fluoroquinolones ?

A

1- QTc prolongation
2-Growing cartilage damage and arthropathy in
children
3- Tendinitis in adults

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11
Q

Ciprofloxacin is an ?

A

Inhibitor of CYP 1A2

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12
Q

What is the Contraindication of fluoroquinolones ?

A

1- QT interval prolongation
2- Severe hepatic functional impairment
3- during pregnancy and lactation
4- Renal function impairment (Moxifloxacin safe in renal imparment
5- Not recommended for age less than 18 years

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13
Q

What is the drug that safe in renal imparment ?

A

Moxifloxacin

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14
Q

What is tha drug Not recommended for age less than 18 years ?

A

fluoroquinolones

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15
Q

What is the drug should not be used in children less than 8 years of age ?

A

tetracyclines

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16
Q

What is the Mechanismof action of Sulfonamides ?

A

Inhibits dihydropetroate synthase

17
Q

What is the uses of sulfonamides ?

A

1- Orally absorbable agents
2- Orally non- absorbable agents like sulfasalazine areuseful for the treatment of ulcerative colitis
3- Topical sulfonamides

18
Q

What is the drug is Orally non- absorbable taht useful for the treatment of ulcerative colitis ?

A

sulfasalazine

19
Q

What is the drug that used in Trachoma and bacterial conjuctivits ?

A

sulfacetamide

20
Q

What is the drug that used in Burn dressing ?

A

Silver sulfadiazine

21
Q

What is the Adverse effects of sulfonamides ?

A

1- Crystalluria
2- Steven Johnson syndrome
3- Hemolysis in patients with G6PD enzyme deficiency
4- Kernicterus

22
Q

What is the Mechanismof action of Trimethoprim ?

A

Inhibits dihydrofolate reductase

23
Q

What is the uses of trimethoprim ?

A

Pneumocystis pneumonia

24
Q

What is the drug of Pneumocystis pneumonia ?

A

trimethoprim

25
Q

Pyrimethamine and sulfadiazine are used in the

treatment of ?

A

toxoplasmosis

26
Q

What is the combination of the drugs that used for falciparum malaria ?

A

pyrimethamine with sulfadoxine

27
Q

What is the Mechanism of action of Sulfonamides ?

A

Inhibits dihydropetroate synthase

28
Q

What is the Mechanism of action of Trimethoprim ?

A

Inhibits dihydrofolate reductase

Pharma 🟣 (15 decks)

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