Anticancer treatment Flashcards

1
Q

What is the anticancer drug that treat Nausea and vomiting ?

A

Ondasetron

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2
Q

What is the drug that treat hemorrhagic cystitis ?

A

Cyclophosphamide

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3
Q

What is the prototype of Alkylating agents ?

A

Cyclophosphamide

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4
Q

Cyclophosphamide is a ?

A

Prodrug

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5
Q

What is the phase of Antimetabolite ?

A

S phase

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6
Q

What is the drug that used in gout to prevent toxicity ?

A

Allopurinol

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7
Q

What is the use of vincristine ?

A

Childhood cancers

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8
Q

What is the uses of vinblastine ?

A

Brest cancer

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9
Q

What is the side effect of vincristine ?

A

Constipation

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10
Q

What is the Anticancer antibiotics that use of breast and lung cancer ?

A

Doxorubicin

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11
Q

What is the uses of Bleomycin ?

A

Hodgkin lymphoma& testicular tumors

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12
Q

What is the side effect of Bleomycin ?

A

pulmonary fibrosis

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13
Q

What is the drugs for hemorrhagic cystitis ?

A

Cyclophosphamide

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14
Q

cardiomyopathy ?

A

Doxorubicin

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15
Q

Neuropathy ?

A

1- Vincristine

2- Oxaliplatin

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16
Q

Pulmonary toxicity ?

17
Q

Pulmonary toxicity ?

18
Q

lung toxicity ?

19
Q

Hemorrhagic cystitis (acroline metabolite) treated by ?

20
Q

alkylating agent ?

A

Cisplatin, carboplatin, oxaliplatin

21
Q

Folic acid analogs ?

A

1- Methotrexate
2- pemetrexed
3- pralatrexat

22
Q

Purine Analogs ?

A

6-Mercaptoguanine
Azathioprine
6-Thioguanine

23
Q

Pyrimidine Analogs ? ุจุงูŠุฑูŠ ุงูƒู„ ูƒุจุณู‡ ุจุนุฏูŠู† ุฑูƒุจ ุงู„ุฌู…ุณ ูˆ ุฑุงุญ ู„ุงุณุชุฑุง ุนุดุงู† ูŠุดุชุฑูŠ ูฅ ูˆุฑุฏุงุช

A

5-Fluorouracil
Capecitabine
Cytarabine
Gemcetabine

24
Q

Mechanism of action: A folic acid antagonist (competitive antagonist of DHFR enzyme) ?

A

Methotrexate

25
we should reduce dose of 6-MP by 50%โ€“75% when used with ?
allopurinol (drug used in gout) to prevent toxicity
26
What is the Aromatase inhibitors ? ุงู„ุฒูˆู„ ูŠุฑู…ูŠ
Anastrozole and Letrozole
27
Used in treatment of postmenopausal women with metastatic breast cancer (1st line drug) ?
Aromatase inhibitors (Anastrozole and Letrozole)
28
Imatinib ?
Acts by inhibiting tyrosine kinase activity
29
Gefitinib ?
Inhibit epidermal growth factor receptor tyrosine kinase
30
Filgrastim ?
granulocyte colony-stimulating factor (rGCSF)
31
What is the use of Filgrastim ?
accelerate recovery of neutropenia if given after chemotherapy
32
Sargramostim (rGMCSF) | is a ?
recombinant granulocyte macrophage colony-stimulating factor
33
Sargramostim (rGMCSF) used to ?
treat neutropenia induced by chemotherapy during the treatment of acute myeloid leukemia
34
Considered for remission in acute leukemia ?
Asparaginase
35
now the standard chemotherapy regimen for Hodgkinโ€™s disease ?
ABVD (Adriamycin, Bleomycin, Vinblastine, Dacarbazine)
36
Erythropoietin (EPO) is used in
anti-cancer treatment with bone marrow suppressive drugs