Anticancer treatment Flashcards
What is the anticancer drug that treat Nausea and vomiting ?
Ondasetron
What is the drug that treat hemorrhagic cystitis ?
Cyclophosphamide
What is the prototype of Alkylating agents ?
Cyclophosphamide
Cyclophosphamide is a ?
Prodrug
What is the phase of Antimetabolite ?
S phase
What is the drug that used in gout to prevent toxicity ?
Allopurinol
What is the use of vincristine ?
Childhood cancers
What is the uses of vinblastine ?
Brest cancer
What is the side effect of vincristine ?
Constipation
What is the Anticancer antibiotics that use of breast and lung cancer ?
Doxorubicin
What is the uses of Bleomycin ?
Hodgkin lymphoma& testicular tumors
What is the side effect of Bleomycin ?
pulmonary fibrosis
What is the drugs for hemorrhagic cystitis ?
Cyclophosphamide
cardiomyopathy ?
Doxorubicin
Neuropathy ?
1- Vincristine
2- Oxaliplatin
Pulmonary toxicity ?
Bleomycin
Pulmonary toxicity ?
Bleomycin
lung toxicity ?
Busulfan
Hemorrhagic cystitis (acroline metabolite) treated by ?
MESNA
alkylating agent ?
Cisplatin, carboplatin, oxaliplatin
Folic acid analogs ?
1- Methotrexate
2- pemetrexed
3- pralatrexat
Purine Analogs ?
6-Mercaptoguanine
Azathioprine
6-Thioguanine
Pyrimidine Analogs ? ุจุงูุฑู ุงูู ูุจุณู ุจุนุฏูู ุฑูุจ ุงูุฌู ุณ ู ุฑุงุญ ูุงุณุชุฑุง ุนุดุงู ูุดุชุฑู ูฅ ูุฑุฏุงุช
5-Fluorouracil
Capecitabine
Cytarabine
Gemcetabine
Mechanism of action: A folic acid antagonist (competitive antagonist of DHFR enzyme) ?
Methotrexate
we should reduce dose of 6-MP by 50%โ75% when used with ?
allopurinol (drug used in gout) to prevent toxicity
What is the Aromatase inhibitors ? ุงูุฒูู ูุฑู ู
Anastrozole and Letrozole
Used in treatment of postmenopausal women with metastatic breast cancer (1st line drug) ?
Aromatase inhibitors (Anastrozole and Letrozole)
Imatinib ?
Acts by inhibiting tyrosine kinase activity
Gefitinib ?
Inhibit epidermal growth factor receptor tyrosine kinase
Filgrastim ?
granulocyte colony-stimulating factor (rGCSF)
What is the use of Filgrastim ?
accelerate recovery of neutropenia if given after chemotherapy
Sargramostim (rGMCSF)
is a ?
recombinant granulocyte macrophage colony-stimulating factor
Sargramostim (rGMCSF) used to ?
treat neutropenia induced by chemotherapy during the treatment of acute myeloid leukemia
Considered for remission in acute leukemia ?
Asparaginase
now the standard chemotherapy regimen for Hodgkinโs disease ?
ABVD (Adriamycin, Bleomycin, Vinblastine, Dacarbazine)
Erythropoietin (EPO) is used in
anti-cancer treatment with bone marrow suppressive drugs