Protamine Sulfate Flashcards
1
Q
Protamine Dosing
A
1 mg protamine neutralizes 100 heparin units
Suggested max dose 250 mg, check ACT
2
Q
Protamine Indications
A
Heparin reversal
3
Q
Protamine Contraindications
A
Prior protamine reactions
4
Q
Protamine Adverse Effects
A
Allergy of fish may cause hypersensitivity reaction
Hypotension, bradycardia = protamine reaction
5
Q
Protamine MOA
A
Strongly basic protein that binds to acidic heparin to for a stable inert salt
Anticoagulant activity of both drugs is lost
6
Q
Protamine Drug Class
A
Protein
Anticoagulant
Heparin antagonist
7
Q
Protamine Source
A
Salmon sperm
8
Q
Protamine Reaction CPB
A
Immediate discontinuation of protamine until hypotensive episode subsides
9
Q
Protamine Administration
A
No more than 50 mg over 10 minutes
Most centers do not follow this
